ArticleJournal of psychiatric research2021
Quadratic relations of BMI with depression and brain volume in children: Analysis of data from the ABCD study.
Article in Journal of psychiatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Three-year outcomes of the randomized phase III SEIPLUS trial of extensive intraoperative peritoneal lavage for locally advanced gastric cancer.Nature communications · 2021Trial
- Clinical and Modifiable Factors Associated With Disability and Relapse in MOGAD: A Multicentre Cohort Study.Annals of clinical and translational neurology · 2026Article
- Bullying victimization and brain development: a longitudinal structural magnetic resonance imaging study from adolescence to early adulthood.Translational psychiatry · 2026Article
- Predicting the degree of trait emotional empathy from cortical features using surface-based morphometry.Scientific reports · 2026Article
- Bullying Victimization and Brain Development: A Longitudinal Structural Magnetic Resonance Imaging Study from Adolescence to Early Adulthood.bioRxiv : the preprint server for biology · 2026Article
- Neurostructural Substrates of Hierarchical Dimensions of Internalizing Symptoms in Youth.Human brain mapping · 2026Article
- Restrained Eating Features and Brain Morphology: A Pediatric Population-Based Study.The International journal of eating disorders · 2025Article
- Longitudinal Sex-at-Birth and Age Analyses of Cortical Structure in the ABCD Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The BMIgap tool to quantify transdiagnostic brain signatures of current and future weight.Nature. Mental health · 2025Article
- Biobehavioral susceptibility for obesity in childhood: Behavioral, genetic and neuroimaging studies of appetite.Physiology & behavior · 2023Review
- Paediatric obesity and metabolic syndrome associations with cognition and the brain in youth: Current evidence and future directions.Pediatric obesity · 2023Review
- Excess BMI in early adolescence adversely impacts maturating functional circuits supporting high-level cognition and their structural correlates.International journal of obesity (2005) · 2023Article
- White matter microstructure shows sex differences in late childhood: Evidence from 6797 children.Human brain mapping · 2023Article
- Network segregation in aging females and evaluation of the impact of sex steroid hormones.Frontiers in human neuroscience · 2023Article
- Age-volume associations in cerebellar lobules by sex and reproductive stage.Brain structure & function · 2022Article
- Weight spectrum and executive function in adolescents: the moderating role of negative emotions.Child and adolescent psychiatry and mental health · 2022Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWeight-related health conditions and depression peak during adolescence and show relations with brain structure. Understanding how these conditions relate to each other prior to adolescence may guide research on the co-development of unhealthy weight conditions (both underweight and overweight) and depression, with a potential brain-based link. This study examines the cross-sectional relations between body mass index (BMI), depressive symptoms, and brain volume (total and regional) to determine whether BMI has a linear or quadratic relation with depressive symptoms and brain volume and how depressive symptoms and brain volume are related.
methodsCross-sectional study using structural magnetic resonance imaging, height and weight to calculate BMI z-scores, and Child Behavior Checklist withdrawn depression scores. Data were from the Adolescent Brain Cognitive Development Study, collected at 21 sites across the United States from 11,875 9- and 10-year-old children recruited as a national sample. Mixed models were used to examine the linear and quadratic effects of BMI z-score on both brain volume (total and regional) and withdrawn depression scores, as well as the relations between brain volume and depression scores. Intracranial volume, age, sex, race, site, and family were included in the models as covariates.
resultsOverall, BMI z-scores showed a quadratic relation with brain volumes and depressive symptoms. When including intracranial volume as a covariate, regional volumes investigated did not follow the same global pattern of effects except for right hippocampus and left lateral orbitofrontal cortex. Total brain volume was negatively related to depressive symptoms.
conclusionsLinks between depressive symptoms and low or high weight could improve our understanding of brain structural differences in depression. These findings also emphasize the importance of including the full spectrum of BMI from underweight to overweight and testing for nonlinear effects in models.
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