ArticleMedical hypotheses2021
Autism Spectrum Disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin.
Article in Medical hypotheses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Parental Experiences of Melatonin Administration to Manage Sleep Disturbances in Autistic Children and Adolescent in the UK.Healthcare (Basel, Switzerland) · 2023Article
- [Autism Spectrum Disorders: What the COVID-19 Pandemic Has Taught Us].Annales medico-psychologiques · 2022Article
- Diversity regained: Precautionary approaches to COVID-19 as a phenomenon of the total environment.The Science of the total environment · 2022Article
- Biological correlates of altered circadian rhythms, autonomic functions and sleep problems in autism spectrum disorder.Annals of general psychiatry · 2022Review
- Brief Report: Impact of COVID-19 in Individuals with Autism Spectrum Disorders: Analysis of a National Private Claims Insurance Database.Journal of autism and developmental disorders · 2022Article
- A Systematic Review on the Impact of the Social Confinement on People with Autism Spectrum Disorder and Their Caregivers during the COVID-19 Pandemic.Brain sciences · 2021Review
- The Coronavirus Disease 2019 (COVID-19): Key Emphasis on Melatonin Safety and Therapeutic Efficacy.Antioxidants (Basel, Switzerland) · 2021Review
- A Pilot Study on Covid and Autism: Prevalence, Clinical Presentation and Vaccine Side Effects.Brain sciences · 2021Article
- Systemic Inflammation and Astrocyte Reactivity in the Neuropsychiatric Sequelae of COVID-19: Focus on Autism Spectrum Disorders.Frontiers in cellular neuroscience · 2021Article
- The "Connectivome Theory": A New Model to Understand Autism Spectrum Disorders.Frontiers in psychiatry · 2021Article
- The Impact of COVID-19 on Sleep in Autistic Adults: Longitudinal Comparisons pre and During Lockdown.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with Autism Spectrum Disorder (ASD) may be particularly prone to develop COVID-19. An unusual extended course of COVID-19 disease illness has been reported in one ASD patient and a group of patients have COVID-19 disease in a neurodevelopmental facility. It has been widely reported that many of those with ASD have substantial sleep disorders with low levels of melatonin and various genetic alterations related to melatonin production have been found. Several lines of evidence point to a substantial role of melatonin in the body's innate defense system including acting as a scavenger, an antioxidant and modulating the immune system. We therefore hypothesize that melatonin deficiency may predispose those ASD patients who have low melatonin output to COVID-19 disease. Potential implications for treatment are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.