ReviewNeuroscience and biobehavioral reviews2021
A salience misattribution model for addictive-like behaviors.
Review in Neuroscience and biobehavioral reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Conditioned accumbal dopamine transients forecast individual preference for drug versus natural rewards and compulsive behavior.Nature neuroscience · 2026Article
- Functional bipartition of medial prefrontal cortex into salience detection and movement gain.bioRxiv : the preprint server for biology · 2026Article
- Uncertainty and reward histories have distinct effects on decisions after wins and losses.Scientific reports · 2026Article
- Motivation, attention, and uncertainty: insights from animal and human research and implications for addiction.Frontiers in psychology · 2026Review
- Prefrontal-centered cortical alterations and network dysconnectivity in cocaine use disorder.Frontiers in psychiatry · 2026Article
- Evaluating the impact of concurrent sucrose availability on operant ethanol self-administration in male and female Long Evans rats.Addiction neuroscience · 2025Article
- Generalized cue reactivity in rat dopamine neurons after opioids.Nature communications · 2025Article
- What does a dollar mean to you? utilizing intrinsic rewards within contingency management.Frontiers in psychiatry · 2025Article
- Generalized cue reactivity in dopamine neurons after opioids.bioRxiv : the preprint server for biology · 2024Article
- Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Adapting to the changing environment is a key component of optimal decision-making. Internal-models that accurately represent and selectively update from behaviorally relevant/salient stimuli may facilitate adaptive behaviors. Anterior cingulate cortex (ACC) and dopaminergic systems may produce these adaptive internal-models through selective updates from behaviorally relevant stimuli. Dysfunction of ACC and dopaminergic systems could therefore produce misaligned internal-models where updates are disproportionate to the salience of the cues. An aspect of addictive-like behaviors is reduced adaptation and, ACC and dopaminergic systems typically exhibit dysfunction in drug-dependents. We argue that ACC and dopaminergic dysfunction in dependents may produce misaligned internal-models such that drug-related stimuli are misattributed with a higher salience compared to non-drug related stimuli. Hence, drug-related rewarding stimuli generate over-weighted updates to the internal-model, while negative feedback and non-drug related rewarding stimuli generate down-weighted updates. This misaligned internal-model may therefore incorrectly reinforce maladaptive drug-related behaviors. We use the proposed framework to discuss ways behavior may be made more adaptive and how the framework may be supported or falsified experimentally.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.