SynthesisInternational journal of cardiology2021
Gender differences in the prevalence of frailty in heart failure: A systematic review and meta-analysis.
Synthesis in International journal of cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Prevalence and associated factors of cognitive frailty in older adults with heart failure: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- Prevalence and risk factors of frailty among cardiac surgery patients: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- Prevalence and Associated Factors of Frailty in Patients with Chronic Heart Failure: A Systematic Review and Meta-Analysis.Reviews in cardiovascular medicine · 2025Pooled it
- Association between natriuretic peptides and C-reactive protein with frailty in heart failure: a systematic review and meta-analysis.Aging clinical and experimental research · 2024Pooled it
- Age and gender effects on echocardiographic and histopathological cardiac phenotypes in healthy adult mice.Animal models and experimental medicine · 2026Article
- Clinical Pharmacology of Heart Failure in Frailty.European cardiology · 2026Review
- Chronic diseases and frailty transitions in community-dwelling older adults: evidence from a national longitudinal cohort study.BMC geriatrics · 2025Article
- Nonlinear association between visceral fat metabolism score and heart failure: insights from LightGBM modeling and SHAP-Driven feature interpretation in NHANES.BMC medical informatics and decision making · 2025Article
- Background and design of the Physical Frailty and Symptom Monitoring and Management Behaviors in Heart Failure (PRISM-HF) study: A mixed methods study.International journal of nursing studies advances · 2025Review
- Clinical Phenotype and Prognostic Significance of Frailty in Transthyretin Cardiac Amyloidosis.JACC. CardioOncology · 2025Article
- Association between sleep quality, sleep duration, and physical frailty among adults aged 50 years and older in India.BMC public health · 2024Article
- Which of these symptom trajectories is not like the other?European journal of cardiovascular nursing · 2024Article
- Assessment of Frailty Among Older Adults in the Physical Activity Daily Trial.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2024Observational
- Sympathetic dysfunction is associated with worse fatigue and early and subtle symptoms in heart failure: an exploratory sex-stratified analysis.European journal of cardiovascular nursing · 2024Article
- The effect of the nutritional status and dietary inflammatory index on frailty and activities of daily living in geriatric outpatients.Irish journal of medical science · 2024Article
- Impact of Frailty on Heart Failure Prognosis: Is Sex Relevant?Current heart failure reports · 2024Review
- Incorporating reproductive system history data into cardiovascular nursing research to advance women's health.European journal of cardiovascular nursing · 2024Article
- Sex Differences in Cardiac and Clinical Phenotypes and Their Relation to Outcomes in Patients with Heart Failure.Journal of personalized medicine · 2024Review
- Weak grip strength predicts higher unplanned healthcare utilization among patients with heart failure.ESC heart failure · 2024Article
- Frailty and heart failure: State-of-the-art review.Journal of cachexia, sarcopenia and muscle · 2023Review
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesThis study quantitatively synthesized literature to identify gender differences in the prevalence of frailty in heart failure (HF).
backgroundThe intersection of frailty and HF continues to garner interest. Almost half of patients with HF are frail; however, gender differences in frailty in HF are poorly understood.
methodsWe performed a literature search to identify studies that reported prevalence of frailty by gender in HF. Random-effects meta-analysis was used to quantify the relative and absolute risk of frailty in women compared with men with HF, overall, and by Physical and Multidimensional Frailty measures. Meta-regression was performed to examine the influence of study age and functional class on relative risk in HF.
resultsTwenty-nine studies involving 8854 adults with HF were included. Overall in HF, women had a 26% higher relative risk of being frail compared with men (95% CI = 1.14-1.38, z = 4.69, p < 0.001, I
conclusionsIn HF, frailty affects women significantly more than men. Future work should focus on elucidating potential causes of gender differences in frailty in HF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.