Evidence map›Paper›PMID 33657389›Full record

ArticleCell metabolism2021

Passing on PCOS: new insights into its epigenetic transmission.

David H Abbott, Daniel A Dumesic

Open access · bronzeAbstract readComment
In one paragraph

Article in Cell metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
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  4. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

David H AbbottDepartment of Obstetrics and Gynecology, Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA. Electronic address: abbott@primate.wisc.edu.
Daniel A DumesicDepartment of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
University of California, Los Angeles · USUniversity of Wisconsin–Madison · US

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
PROJECT 4: ANDROGEN EXCESS IN ADIPOGENIC DYSFUNCTION IN PCOS WOMENP50HD071836 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI STOUFFER, RICHARD L · 2014 to 2021
$14.7M
Neurosteroid Regulation of Adiposity, Glucose Homeostasis and Energy Expenditure in PrimatesR01DK121559 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI LEVINE, JON E · 2019 to 2023
$3.0M
PROJECT 4: ANDROGEN EXCESS IN ADIPOGENIC DYSFUNCTION IN PCOS WOMENU54HD071836 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI BETHEA, CYNTHIA LOUISE · 2013 to 2013
$1.9M
Whole exome analyses in naturally occurring hyperandrogenic female monkeysR21HD102172 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI ABBOTT, DAVID H, LEVINE, JON E · 2020 to 2021
$400k
NICHD NIH HHS P50 HD071836NICHD NIH HHS R21 HD102172NICHD NIH HHS U54 HD071836NIDDK NIH HHS R01 DK121559NIH HHS P51 OD011106
6 · The paper itself

Abstract

Polycystic ovary syndrome (PCOS) is a prevalent reproductive-metabolic disorder with poorly understood etiology. Mimouni et al. (2021) demonstrate global genomic DNA hypomethylation in women with PCOS and their daughters, and in F3 generation PCOS-like mice, together with substantial normalization of PCOS-like mice by methyl donor dietary supplementation.

Indexed as

Polycystic Ovary SyndromeAnimalsDNA MethylationEpigenesis, GeneticEpigenomicsFemaleHumansMice

Identifiers

PMID33657389
PMCPMC9133658
OpenAlexW3134220413

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.