Evidence map›Paper›PMID 33657386›Full record

ArticleCell metabolism2021

Proton pump inhibitor use status does not modify the microbiome signature for cirrhosis.

Tae Gyu Oh, Susy M Kim, Annette R Atkins, Ruth T Yu, Michael Downes, Ronald M Evans, Rohit Loomba

Abstract readLetterComment
PubMed Publisher
In one paragraph

Article in Cell metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Tae Gyu OhGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Susy M KimNAFLD Research Center, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Annette R AtkinsGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Ruth T YuGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Michael DownesGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Ronald M EvansGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address: evans@salk.edu.
Rohit LoombaNAFLD Research Center, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: roloomba@ucsd.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oh et al. address concerns about the influence of proton pump inhibitor (PPI) use on a gut microbiome signature for cirrhosis. By removing PPI using subjects from the training cohort and retraining a 19-species Random Forest model, they demonstrate the impact of PPI usage on the signature's diagnostic accuracy is minimal.

Indexed as

Gastrointestinal MicrobiomeMicrobiotaCohort StudiesHumansLiver CirrhosisProton Pump InhibitorsProton Pump Inhibitors

Identifiers

PMID33657386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.