ArticleCell reports2021
Omnitemporal choreographies of all five STIM/Orai and IP
Open access · goldAbstract readComparative StudyVideo-Audio Media
In one paragraph
Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
9.0field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 91 citations in OpenAlex.
- Research progress on the role and mechanism of STIM and Orai protein-mediated store-operated calcium entry in cardiovascular diseases.Channels (Austin, Tex.) · 2026Review
- A Quartet of Native Orai Channel Isoforms Orchestrates Graded NFAT Activation and Transcription.bioRxiv : the preprint server for biology · 2026Article
- The nonexcitable smooth muscle: remodeling the smooth muscle ion transport toolkit in disease.Physiological reviews · 2026Review
- Stochastic intracellular calcium dynamics show preserved structures identified by deep learning classification.PLoS computational biology · 2026Article
- Orai storeoperated CaChannels (Austin, Tex.) · 2025Review
- Endothelial CYB5R3 couples store-operated calcium entry to TRPV2 activation and vascular fitness.bioRxiv : the preprint server for biology · 2025Article
- Endothelial Trauma Depends on Surface Charge and Extracellular Calcium Levels.bioRxiv : the preprint server for biology · 2025Article
- STIM-IP3R crosstalk regulates migration of breast cancer cells.The Journal of cell biology · 2025Article
- The machinery of healthy vasoconstriction: an overview.Pflugers Archiv : European journal of physiology · 2025Review
- Loss of STIM2, but not of STIM1, drives colorectal cancer metastasis through metabolic reprogramming and the ATF4 ER stress pathway.Science signaling · 2025Article
- A subset of Orai1α and Orai1β subunits heteromerizes to form CRAC channels.Cell communication and signaling : CCS · 2025Article
- Jaw1 accelerates the reaction speed of the CaScientific reports · 2025Article
- CaBiomedicines · 2025Review
- Computational Model of Complex Calcium Dynamics: Store Operated CaCell biochemistry and biophysics · 2025Article
- Feedback modulation of Orai1α and Orai1β protein content mediated by STIM proteins.Journal of cellular physiology · 2025Article
- A bright cyan fluorescence calcium indicator for mitochondrial calcium with minimal interference from physiological pH fluctuations.Biophysics reports · 2024Article
- New insights into the stromal interaction molecule 2 function and its impact on the immunomodulation of tumor microenvironment.Cell & bioscience · 2024Review
- Calcium channel signalling at neuronal endoplasmic reticulum-plasma membrane junctions.Biochemical Society transactions · 2024Review
- Article
- Role of KDM2B epigenetic factor in regulating calcium signaling in prostate cancer cells.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Scott M EmrichDepartment of Cellular and Molecular Physiology, the Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
Ryan E YoastDepartment of Cellular and Molecular Physiology, the Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
Ping XinDepartment of Cellular and Molecular Physiology, the Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
Vikas ArigeDepartment of Pharmacology and Physiology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA.
Larry E WagnerDepartment of Pharmacology and Physiology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA.
Nadine HempelDepartment of Pharmacology, the Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA; Penn State Cancer Institute, the Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
Donald L GillDepartment of Cellular and Molecular Physiology, the Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
James SneydDepartment of Mathematics, The University of Auckland, 38 Princes Street, Auckland 1010, New Zealand.
David I YuleDepartment of Pharmacology and Physiology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA.
Mohamed TrebakDepartment of Cellular and Molecular Physiology, the Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA; Penn State Cancer Institute, the Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA. Electronic address: mtrebak@psu.edu.
Pennsylvania State University · USUniversity of Rochester · USUniversity of Auckland · NZ
Funding
An experimental/computational approach for understanding salivary fluid secretionR01DE019245 · NIDCR · UNIVERSITY OF ROCHESTER · PI David I Yule · 2008 to 2026
$9.7MCa2+ Signaling Networks in Health and DiseaseR35HL150778 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TREBAK, MOHAMED · 2020 to 2025
$5.4MUnderstanding Store-Operated Calcium Signal TransductionR35GM131916 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GILL, DONALD L · 2019 to 2023
$2.9MRegulation of mitochondrial redox homeostasis and signaling in metastatic ovarian cancerR01CA242021 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HEMPEL, NADINE · 2020 to 2024
$1.8MStructural Basis of Peripheral Coupling Sites Regulating Arterial Smooth Muscle Contractility (A1)R01HL137852 · NHLBI · UNIVERSITY OF NEVADA RENO · PI EARLEY, SCOTT · 2018 to 2020
$1.6MNCI NIH HHS R01 CA242021NHLBI NIH HHS R01 HL137852NHLBI NIH HHS R35 HL150778NIDCR NIH HHS R01 DE019245NIGMS NIH HHS R35 GM131916
Abstract
Stromal-interaction molecules (STIM1/2) sense endoplasmic reticulum (ER) Ca
Indexed as
Calcium SignalingCalcium ChannelsCarbacholHEK293 CellsHumansInositol 1,4,5-Trisphosphate ReceptorsMembrane PotentialsModels, BiologicalMuscarinic AgonistsNeoplasm ProteinsNFATC Transcription FactorsORAI1 ProteinORAI2 ProteinProtein BindingReceptor Cross-TalkStromal Interaction Molecule 1Calcium ChannelsCarbacholInositol 1,4,5-Trisphosphate ReceptorsMuscarinic AgonistsNeoplasm ProteinsNFATC Transcription FactorsORAI1 ProteinORAI1 protein, humanORAI2 ProteinORAI2 protein, humanOrai3 protein, humanSTIM1 protein, humanSTIM2 protein, humanStromal Interaction Molecule 1Stromal Interaction Molecule 2calcium entrycalcium oscillationscalcium signalingCRAC channelsIP(3)RNFATOraiSOCESTIM
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What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.