Evidence map›Paper›PMID 33657363›Full record

ArticleCell reports2021

Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine.

Michael J McFadden, Alexa B R McIntyre, Haralambos Mourelatos, Nathan S Abell, Nandan S Gokhale, Hélène Ipas, Blerta Xhemalçe, Christopher E Mason, Stacy M Horner

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 81 citations in OpenAlex.

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  16. UFMylation promotes orthoflavivirus infectious particle production.bioRxiv : the preprint server for biology · 2025
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  17. When animal viruses meet NVeterinary research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Michael J McFaddenDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
Alexa B R McIntyreDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10021, USA; Tri-Institutional Program in Computational Biology and Medicine, New York, NY 10021, USA.
Haralambos MourelatosWeill Cornell/Rockefeller/Memorial Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY 10021, USA.
Nathan S AbellDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA; Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305-5324, USA.
Nandan S GokhaleDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
Hélène IpasDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Blerta XhemalçeDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Christopher E MasonDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10021, USA; Tri-Institutional Program in Computational Biology and Medicine, New York, NY 10021, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA.
Stacy M HornerDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: stacy.horner@duke.edu.
The University of Texas at Austin · USDuke University Hospital · USCornell University · USDuke Medical Center · USTri-Institutional PhD Program in Chemical Biology · USWeill Cornell Medicine · US

Funding

Weill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1M
Viral Oncology Training GrantT32CA009111 · NCI · DUKE UNIVERSITY · PI LUFTIG, MICAH A. · 1985 to 2023
$8.9M
Defining the role of the RNA modification N6-methyladenosine in the hepatitis C virus lifecycleR01AI125416 · NIAID · DUKE UNIVERSITY · PI Stacy Michelle Horner · 2016 to 2026
$5.5M
The Spatiotemporal Landscape of the Human Brain EpitranscriptomeR01MH117406 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI MASON, CHRISTOPHER EDWARD · 2018 to 2022
$3.3M
Elucidating mechanisms of microRNA pathway deregulation in human cellsR01GM127802 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI XHEMALCE, BLERTA · 2018 to 2022
$1.7M
Mapping the RNA modification N6-methyladenosine during Zika virus infectionR21AI129851 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI HORNER, STACY MICHELLE, MASON, CHRISTOPHER EDWARD · 2017 to 2018
$469k
NCI NIH HHS T32 CA009111NIAID NIH HHS R01 AI125416NIAID NIH HHS R21 AI129851NIGMS NIH HHS R01 GM127802NIGMS NIH HHS T32 GM007739NIMH NIH HHS R01 MH117406
6 · The paper itself

Abstract

Type I interferons (IFNs) induce hundreds of IFN-stimulated genes (ISGs) in response to viral infection. Induction of these ISGs must be regulated for an efficient and controlled antiviral response, but post-transcriptional controls of these genes have not been well defined. Here, we identify a role for the RNA base modification N6-methyladenosine (m

Indexed as

Protein BiosynthesisRNA Processing, Post-TranscriptionalTranscription, GeneticA549 CellsAdenosineAnimalsAntigens, DifferentiationAntiviral AgentsChlorocebus aethiopsHEK293 CellsHost-Pathogen InteractionsHumansInterferon-betaMethyltransferasesRNA-Binding ProteinsVero CellsAdenosineAntigens, DifferentiationAntiviral AgentsInterferon-betaleu-13 antigenMethyltransferasesMETTL14 protein, humanMETTL3 protein, humanN-methyladenosineRNA-Binding ProteinsYTHDF1 protein, humanInterferonISGsm6AN6-methyladenosineTranslationYTHDF1

Identifiers

PMID33657363
PMCPMC7981787
OpenAlexW3133744017

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.