Evidence map›Paper›PMID 33656963›Full record

ArticleSeminars in ophthalmology2021

Emerging therapies for amblyopia.

Michelle M Falcone, David G Hunter, Eric D Gaier

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Seminars in ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07226141 (Valproate for the Treatment of Residual Amblyopia), which is not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07226141 phase1 / phase2recruitingnot on this mapstarted 2026, after this paper: background citation

Valproate for the Treatment of Residual Amblyopia

TypeinterventionalSponsorBoston Children's HospitalRan2026 to 2027Enrolled28ConditionsAmblyopia, Amblyopia Unilateral, Amblyopia, Anisometropic, Amblyopia StrabismicArmsValproate, Placebo, Patch
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Interventions for improving adherence to amblyopia treatments in children.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Guideline
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Childhood amblyopia: A systematic review of recent management options.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Michelle M FalconeDepartment of Ophthalmology, Boston Children's Hospital, Boston, United States.
David G HunterDepartment of Ophthalmology, Boston Children's Hospital, Boston, United States.
Eric D GaierDepartment of Ophthalmology, Boston Children's Hospital, Boston, United States.
Boston Children's Hospital · USBoston Children's Museum · USHarvard University · US

Funding

Exploiting principles of timing-dependent synaptic plasticity to treat amblyopiaK08EY030164 · NEI · BOSTON CHILDREN'S HOSPITAL · PI GAIER, ERIC DEAN · 2019 to 2023
$1.2M
NEI NIH HHS K08 EY030164
6 · The paper itself

Abstract

Traditional therapies to treat amblyopia, such as optical correction or occlusion/penalization of the non-amblyopic eye, are efficacious but are not without limitations such as poor adherence and decreased success with increasing age. Recently, there has been an interest in new amblyopia therapies, some using binocular techniques, through a variety of platforms including video games, movies, and virtual reality. Overall, available efficacy results for these treatments are highly variable.

Indexed as

AmblyopiaVideo GamesHumansVision, BinocularVisual AcuityAmblyopiaBinocular therapyDichoptic therapyPerceptual learningVirtual reality

Identifiers

PMID33656963
PMCPMC8122041
OpenAlexW3133920655

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.