Evidence map›Paper›PMID 33656855›Full record

ArticleBiochemistry2021

Mechanism and Inhibition of Human Methionine Adenosyltransferase 2A.

Courtney N Niland, Agnidipta Ghosh, Sean M Cahill, Vern L Schramm

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Subcellular one carbon metabolism in cancer, aging and epigenetics.Frontiers in epigenetics and epigenomics · 2024
    Article
  5. OrganophosphorusFrontiers in chemistry · 2024
    Article
  6. Article
  7. Article
  8. Analogs ofMolecular biology · 2022
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Courtney N NilandDepartment of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, United States.ORCID 0000-0002-0949-8779
Agnidipta GhoshDepartment of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, United States.ORCID 0000-0002-7753-0240
Sean M CahillDepartment of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, United States.
Vern L SchrammDepartment of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, United States.ORCID 0000-0002-8056-1929
Albert Einstein College of Medicine · US

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI STEVEN C. ALMO · 1985 to 2026
$111.2M
TRANSITION STATE ANALYSIS OF ENZYMATIC REACTIONSR01GM041916 · NIGMS · YESHIVA UNIVERSITY · PI SCHRAMM, VERN L. · 1989 to 2023
$10.0M
Console and probe upgrade for 600 MHz NMRS10OD016305 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI COWBURN, DAVID · 2014 to 2014
$595k
Design and Development of Inhibitors of Methionine Adenosyltransferase for Cancer TreatmentF32CA225149 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI NILAND, COURTNEY NICOLE · 2018 to 2020
$171k
NCI NIH HHS F32 CA225149NCI NIH HHS P30 CA013330NIGMS NIH HHS R01 GM041916NIH HHS S10 OD016305
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adenosine TriphosphateBinding SitesDiphosphatesEnzyme InhibitorsHumansHydrolysisKineticsMethionine AdenosyltransferasePolyphosphatesProtein ConformationS-AdenosylmethionineAdenosine TriphosphateDiphosphatesdiphosphoric acidEnzyme InhibitorsMAT2A protein, humanMethionine AdenosyltransferasePolyphosphatesS-Adenosylmethioninetriphosphoric acid

Identifiers

PMID33656855
PMCPMC8315116
OpenAlexW3133692752

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.