Evidence map›Paper›PMID 33656713›Full record

ArticleAdvances in experimental medicine and biology2021

Relationship Between COVID-19 and Angiotensin-Converting Enzyme 2: A Scoping Review.

Asma Shojaee, Amir Vahedian-Azimi, Fakhrudin Faizi, Farshid Rahimi-Bashar, Alireza Shahriary, Hadi Esmaeili Gouvarchin Galeh, Batool Nehrir, Paul C Guest, Amirhossein Sahebkar

Abstract readScoping Review
PubMed Publisher
In one paragraph

Article in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. COVID-19 and the liver: What do we know so far?World journal of hepatology · 2021
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Asma ShojaeeStudent Research Committee, Nursing Faculty, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Amir Vahedian-AzimiTrauma Research Center, Nursing Faculty, Baqiyatallah University of Medical Sciences, Tehran, Iran. amirvahedian63@gmail.com.
Fakhrudin FaiziAtherosclerosis research center, Nursing Faculty, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Farshid Rahimi-BasharAnesthesia and Critical Care Department, Hamadan University of Medical Sciences, Hamadan, Iran.
Alireza ShahriaryChemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Hadi Esmaeili Gouvarchin GalehApplied virology research center, Baqiyatallah University of medical science, Tehran, Iran.
Batool NehrirHealth Management Research Center, Nursing Faculty, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Paul C GuestLaboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.
Amirhossein SahebkarNeurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. amir_saheb2000@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Following the outbreaks of SARS-CoV in 2002 and MERS-CoV in 2012, the COVID-19 pandemic caused by the SARS-CoV-2 virus has become an increasing threat to human health around the world. Numerous studies have shown that SARS-CoV-2 appears similar to the SARS-CoV as it uses angiotensin converting enzyme 2 (ACE2) as a receptor to gain entry into cells. The main aims of this scoping review were to identify the primary hosts of coronaviruses, the relationship between the receptor binding domain of coronaviruses and ACE2, the organ specificity of ACE2 expression compared with clinical manifestations of the disease, and to determine if this information can be used in the development of novel treatment approaches for the COVID-19 pandemic.

Indexed as

COVID-19PandemicsAngiotensin-Converting Enzyme 2HumansPeptidyl-Dipeptidase ASARS-CoV-2Spike Glycoprotein, CoronavirusAngiotensin-Converting Enzyme 2Peptidyl-Dipeptidase ASpike Glycoprotein, CoronavirusACE2Angiotensin converting enzyme 2Bat-SARS-CoVCOVID-19Receiver connection rangeSARS-CoVSARS-CoV-2SARS-CoV-likeSpike protein

Identifiers

PMID33656713

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.