Evidence map›Paper›PMID 33656631›Full record

ArticleCell and tissue banking2022

Tissue engineered human ear pinna derived from decellularized goat ear cartilage: clinically useful and biocompatible auricle construct.

Nilesh C Bhamare, Kishor R Tardalkar, Jeevitaa Kshersagar, Shashikant R Desai, Tejas B Marsale, Mansingraj S Nimbalkar, Shimpa Sharma, Meghnad G Joshi

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Article in Cell and tissue banking, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Tissue engineering of human ear pinna.Cell and tissue banking · 2022
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Nilesh C Bhamare *Department of Stem Cells and Regenerative Medicine, D Y Patil Education Society (Deemed University), E 869, D. Y. Patil Vidyanagar, Kasba Bawda, Kolhapur, MS, 416006, India.
Kishor R Tardalkar *Department of Stem Cells and Regenerative Medicine, D Y Patil Education Society (Deemed University), E 869, D. Y. Patil Vidyanagar, Kasba Bawda, Kolhapur, MS, 416006, India.
Jeevitaa KshersagarDepartment of Stem Cells and Regenerative Medicine, D Y Patil Education Society (Deemed University), E 869, D. Y. Patil Vidyanagar, Kasba Bawda, Kolhapur, MS, 416006, India.
Shashikant R DesaiStem Plus Biotech, SMK Commercial Complex, C/S No. 1317/2, Near Shivaji Maharaj Putla, Bus Stand Road, Gaon Bhag, Sangli, MS, 416416, India.
Tejas B MarsaleDepartment of Stem Cells and Regenerative Medicine, D Y Patil Education Society (Deemed University), E 869, D. Y. Patil Vidyanagar, Kasba Bawda, Kolhapur, MS, 416006, India.
Mansingraj S NimbalkarDepartment of Botany, Shivaji University, Vidyanagar, Kolhapur, 416004, India.
Shimpa SharmaDepartment of Medicine, D Y Patil Medical College, D Y Patil Education Society (Deemed University), E 869, D. Y. Patil Vidyanagar, Kasba Bawda, Kolhapur, MS, 416006, India.
Meghnad G JoshiDepartment of Stem Cells and Regenerative Medicine, D Y Patil Education Society (Deemed University), E 869, D. Y. Patil Vidyanagar, Kasba Bawda, Kolhapur, MS, 416006, India. drmeghnadjoshi@gmail.com.ORCID http://orcid.org/0000-0001-6060-244X
D.Y. Patil Education Society · INICAR Research Complex for NEH Region · INShivaji University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Surgery of the entire ear pinna even today presents a challenge to reconstructive surgeons, in the absence of a universally acceptable, quality construct for clinical use. In this article, the authors present a technique to generate a flexible, human size ear with the aim to meet this limitation for ear reconstructive surgeries. The construct was engineered by using a decellularized goat ear cartilage. This was characterized by hematoxylin-eosin (H/E), diamidino-2-phenylindole (DAPI), Masson's trichrome (MT), Alcian Blue (AB) staining and Scanning Electron Microscopy (SEM) for extracellular matrix (ECM) analysis. The decellularization protocol followed yielded complete removal of all cellular components without changing the properties of the ECM. In vivo biocompatibility of the ear pinna showed demonstrable recellularization. Recellularization was tracked using HE, DAPI, MT, AB staining, toluidine staining, SEM, vascular-associated protein (VAP) and CD90

Indexed as

Ear AuricleTissue ScaffoldsAnimalsEar CartilageExtracellular MatrixGoatsHumansTissue EngineeringBiocompatibilityCartilageDecellularized scaffoldEar pinnaReconstructive surgery

Identifiers

PMID33656631
OpenAlexW3134370386

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.