Evidence map›Paper›PMID 33656622›Full record

ArticleBrain topography2021

Effects on Motor Control of Personalized Neuromodulation Against Multiple Sclerosis Fatigue.

Matteo Padalino, Carla Scardino, Giancarlo Zito, Andrea Cancelli, Carlo Cottone, Massimo Bertoli, Eugenia Gianni, Teresa L'Abbate, Elisabetta Trombetta, Camillo Porcaro and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Brain topography, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Matteo Padalino *LET'S-ISTC-CNR, via Palestro 32, 00185, Rome, Italy.
Carla Scardino *LET'S-ISTC-CNR, via Palestro 32, 00185, Rome, Italy.
Giancarlo ZitoComplex Operative Unit of Neurology, Emergency Department, San Camillo de Lellis Hospital, Viale Kennedy, Rieti, 02100, RI, Italy.
Andrea CancelliLET'S-ISTC-CNR, via Palestro 32, 00185, Rome, Italy.
Carlo CottoneLET'S-ISTC-CNR, via Palestro 32, 00185, Rome, Italy.
Massimo BertoliLET'S-ISTC-CNR, via Palestro 32, 00185, Rome, Italy.
Eugenia GianniLET'S-ISTC-CNR, via Palestro 32, 00185, Rome, Italy.
Teresa L'AbbateLET'S-ISTC-CNR, via Palestro 32, 00185, Rome, Italy.
Elisabetta TrombettaLET'S-ISTC-CNR, via Palestro 32, 00185, Rome, Italy.
Camillo PorcaroLET'S-ISTC-CNR, via Palestro 32, 00185, Rome, Italy.
Fabiano BiniDepartment of Mechanical and Aerospace Engineering, "Sapienza" University of Rome, Rome, Italy.
Franco MarinozziDepartment of Mechanical and Aerospace Engineering, "Sapienza" University of Rome, Rome, Italy.
Maria Maddalena FilippiComplex Operative Unit of Neurology, Emergency Department, San Camillo de Lellis Hospital, Viale Kennedy, Rieti, 02100, RI, Italy.
Franca TecchioLET'S-ISTC-CNR, via Palestro 32, 00185, Rome, Italy. franca.tecchio@cnr.it.ORCID 0000-0002-1325-5059
Istituto di Scienza e Tecnologie dell'Informazione "Alessandro Faedo" · ITSapienza University of Rome · ITEllis Hospital · USIstituto di Ortofonologia · ITMarche Polytechnic University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fatigue is a hidden symptom of Multiple Sclerosis (MS) disease that nevertheless impacts severely on patients' everyday life. Evidence indicates the involvement of the sensorimotor network and its inter-nodes communication at the basis of this symptom. Two randomized controlled trials (RCTs) showed that the personalized neuromodulation called Fatigue Relief in Multiple Sclerosis (FaReMuS) efficaciously fights multiple sclerosis (MS) fatigue. By this Proof of Concept study, we tested whether FaReMuS reverts the alteration of the brain-muscular synchronization previously observed occurring with fatigue. The cortico muscular coherence (CMC) was studied in 11 patients before and after FaReMuS, a 5-day tDCS (1.5 mA, 15 min per day) anodal over the whole body's somatosensory representation (S1) via a personalized MRI-based electrode (35 cm

Indexed as

Multiple SclerosisTranscranial Direct Current StimulationBrainFatigueHumansMagnetic Resonance ImagingElectroencephalography (EEG)Electromyography (EMG)Fatigue relief in multiple sclerosis [FaReMuS]Modified fatigue impact scale (mFIS)Personalized regional electrode (RePE)Randomized controlled trials (RCT)Transcranial direct current stimulation (tDCS)

Identifiers

PMID33656622
OpenAlexW3134530890

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.