Evidence map›Paper›PMID 33656620›Full record

ArticleJournal of assisted reproduction and genetics2021

Blastocyst conversion rate and ploidy in patients with structural rearrangements.

Iris G Insogna, A Lanes, L Dobson, E S Ginsburg, C Racowsky, E Yanushpolsky

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Structural rearrangements affect blastocyst development.Archives of gynecology and obstetrics · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Iris G InsognaBrigham and Women's Hospital, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Harvard Medical School, 3rd floor ASB, 75 Francis Street, Boston, MA, 02115, USA. iinsogna@partners.org.ORCID http://orcid.org/0000-0002-4961-7584
A LanesBrigham and Women's Hospital, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Harvard Medical School, 3rd floor ASB, 75 Francis Street, Boston, MA, 02115, USA.
L DobsonBrigham and Women's Hospital, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Harvard Medical School, 3rd floor ASB, 75 Francis Street, Boston, MA, 02115, USA.
E S GinsburgBrigham and Women's Hospital, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Harvard Medical School, 3rd floor ASB, 75 Francis Street, Boston, MA, 02115, USA.
C RacowskyBrigham and Women's Hospital, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Harvard Medical School, 3rd floor ASB, 75 Francis Street, Boston, MA, 02115, USA.
E YanushpolskyBrigham and Women's Hospital, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Harvard Medical School, 3rd floor ASB, 75 Francis Street, Boston, MA, 02115, USA.
Brigham and Women's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe primary objective of this study was to test the hypotheses that compared to IVF cycles undergoing preimplantation genetic testing for aneuploidy (PGT-A) with or without testing for monogenic disorders (PGT-M), IVF cycles undergoing PGT for structural rearrangements (PGT-SR) will have (1) a poorer blastocyst conversion rate and (2) fewer usable blastocysts available for transfer. Secondarily, the study aimed to compare pregnancy outcomes among PGT groups. PATIENTS: Retrospective cohort study including cycles started from January 1, 2012, to March 30, 2020, with the intent of pursuing PGT-A, PGT-A with PGT-M, and PGT-SR, with trophectoderm biopsy on days 5 or 6.

resultsA total of 658 women underwent 902 cycles, including 607 PGT-A, 216 PGT-A&M, and 79 PGT-SR cycles. When compared with the blastocyst conversion rate for the PGT-A group (59.4%), and after adjustment for patient age, total number of mature oocytes, BMI, and ICSI, there were no significant differences for either the PGT-A&M (69.7%, aRR 1.03, 95% CI 0.96-1.10) or PGT-SR (63.2%, aRR1.04, 95% CI 0.96-1.13) groups. Compared to the PGT-A group, the proportion of usable blastocysts was statistically significantly lower in the PGT-SR group: 35.1% versus 24.4% (aRR 0.57, 95% CI 0.46-0.71) and the PGT-A&M group: 35.1% versus 31.5% (aRR 0.68, 95% CI 0.58-0.81). Implantation, pregnancy, and miscarriage rates were equivalent for all groups.

conclusionPatients with structural rearrangements have similar blastocyst development but significantly fewer usable blastocysts available for transfer compared to PGT-A testers. Nevertheless, with the transfer of a usable embryo, PGT-SR testers perform as well as those testing for PGT-A.

Indexed as

Chromosome AberrationsEmbryo Culture TechniquesPreimplantation DiagnosisAbortion, SpontaneousAdultAneuploidyBlastocystEmbryo ImplantationEmbryo TransferFemaleFertilization in VitroGenetic TestingHumansLive BirthPloidiesPregnancyEuploidyPreimplantation genetic testingReciprocal translocationsRobertsonian translocationsStructural rearrangementsTranslocations

Identifiers

PMID33656620
PMCPMC8190241
OpenAlexW3135579165

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.