Evidence map›Paper›PMID 33656436›Full record

ArticleMicrobial genomics2021

The structure and diversity of strain-level variation in vaginal bacteria.

Brett A Tortelli, Amanda L Lewis, Justin C Fay

Open access · goldAbstract read
In one paragraph

Article in Microbial genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. mBio · 2026
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  4. Article
  5. Sphingolipid-mediated vesiculation in multidrug-resistantApplied and environmental microbiology · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. All Properties of Infertility Microbiome in a Review Article.Journal of clinical laboratory analysis · 2025
    Review
  10. Review
  11. mSystems · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Persistence andmSystems · 2022
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Brett A TortelliDepartment of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Amanda L LewisDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
Justin C FayDepartment of Biology, University of Rochester, Rochester, NY 14627, USA.
Washington University in St. Louis · USUniversity of Rochester · US

Funding

ROLES OF SIALIDASE IN G. VAGINALIS-HOST INTERACTIONS DURING BACTERIAL VAGINOSISR01AI114635 · NIAID · WASHINGTON UNIVERSITY · PI LEWIS, AMANDA L., LEWIS, WARREN G · 2015 to 2025
$5.9M
Yeast-bacterial associations within the gravid vaginal microbiome and risk of preterm birth.F30HD094435 · NICHD · WASHINGTON UNIVERSITY · PI TORTELLI, BRETT A · 2018 to 2021
$158k
NIAID NIH HHS R01 AI114635NICHD NIH HHS F30 HD094435
6 · The paper itself

Abstract

The vaginal microbiome plays an important role in human health and species of vaginal bacteria have been associated with reproductive disease. Strain-level variation is also thought to be important, but the diversity, structure and evolutionary history of vaginal strains is not as well characterized. We developed and validated an approach to measure strain variation from metagenomic data based on SNPs within the core genomes for six species of vaginal bacteria:

Indexed as

MicrobiotaAdultBacteriaCohort StudiesFemaleHumansPhylogenyPregnancyVaginaYoung Adultmicrobiomepopulation structurestrain diversityvaginal bacteria

Identifiers

PMID33656436
PMCPMC8190618
OpenAlexW3134555374

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.