ArticleCirculation research2021
Kynurenine Relaxes Arteries of Normotensive Women and Those With Preeclampsia.
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In one paragraph
Article in Circulation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Role of microbial metabolites in the pathogenesis of hypertensive disorders of pregnancy: From short‑chain fatty acids to tryptophan metabolites (Review).Molecular medicine reports · 2026Review
- Tryptophan metabolism: A hidden regulator of female reproductive health beyond fertility.Chinese medical journal · 2026Review
- Potassium channels in vascular smooth muscle cells.Physiological reviews · 2026Review
- The placental tryptophan pathway across gestation: implications for pregnancy outcomes.Human reproduction update · 2026Review
- VasoTracker 2: Open-source software and hardware for tracking blood vessel diameter and assessing vascular function.The Journal of physiology · 2025Article
- Calcium Homeostasis Machinery in the Human Uterus-A Potential Therapeutic Target in Endometrial Cancer.International journal of molecular sciences · 2025Review
- Fructose-1,6-bisphosphate reverses hypotensive effect caused by L-kynurenine in Wistar male rats.Physiological reports · 2024Article
- First trimester maternal tryptophan metabolism and embryonic and fetal growth: the Rotterdam Periconceptional Cohort (Predict Study).Human reproduction (Oxford, England) · 2024Observational
- Cycling matters: Sex hormone regulation of vascular potassium channels.Channels (Austin, Tex.) · 2023Review
- Novel mechanism of increased preeclampsia risk after kidney donation.Kidney international · 2023Article
- The curious case of tryptophan in pregnancy.The Journal of clinical investigation · 2022Article
- Impaired renal reserve contributes to preeclampsia via the kynurenine and soluble fms-like tyrosine kinase 1 pathway.The Journal of clinical investigation · 2022Article
- Unbalanced IDO1/IDO2 Endothelial Expression and Skewed Keynurenine Pathway in the Pathogenesis of COVID-19 and Post-COVID-19 Pneumonia.Biomedicines · 2022Review
- Tryptophan regulatesProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Differential Distribution of Tryptophan-Metabolites in Fetal and Maternal Circulations During Normotensive and Preeclamptic Pregnancies.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- The Footprint of Kynurenine Pathway in Cardiovascular Diseases.International journal of tryptophan research : IJTR · 2022Review
- The Function of the Kynurenine Pathway in the Placenta: A Novel Pharmacotherapeutic Target?International journal of environmental research and public health · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Stephanie A WortonMaternal & Fetal Health Research Centre, Division of Developmental Biology & Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom (S.A.W., S.L.G., A.E.P.H., M.W., J.E.M.).
Harry A T PritchardDivision of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom (H.A.T.P., M.A., A.G.).
Susan L GreenwoodMaternal & Fetal Health Research Centre, Division of Developmental Biology & Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom (S.A.W., S.L.G., A.E.P.H., M.W., J.E.M.).
Mariam AlakrawiDivision of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom (H.A.T.P., M.A., A.G.).
Alexander E P HeazellMaternal & Fetal Health Research Centre, Division of Developmental Biology & Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom (S.A.W., S.L.G., A.E.P.H., M.W., J.E.M.).
Mark WareingMaternal & Fetal Health Research Centre, Division of Developmental Biology & Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom (S.A.W., S.L.G., A.E.P.H., M.W., J.E.M.).
Adam GreensteinManchester University Hospital NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom (S.A.W., A.E.P.H., A.G., J.E.M.).
Jenny E MyersMaternal & Fetal Health Research Centre, Division of Developmental Biology & Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom (S.A.W., S.L.G., A.E.P.H., M.W., J.E.M.).
Manchester Academic Health Science Centre · GBSt Mary's Hospital · GBTwitter (United States) · US
Funding
British Heart Foundation FS/12/81/29882British Heart Foundation PG/15/109/31931British Heart Foundation PG/18/7/33535Medical Research Council MR/N020685/1
Abstract
[Figure: see text].
Indexed as
Vasodilation15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidAdenylyl Cyclase InhibitorsAdultCalcium Channel BlockersEndothelium, VascularFemaleHumansIndolesKynurenineMuscle, Smooth, VascularMyometriumOmentumPeptidesPre-EclampsiaPregnancy15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidAdenylyl Cyclase InhibitorsCalcium Channel BlockersiberiotoxinIndolesKynureninepaxillinePeptidesRyanodine Receptor Calcium Release ChannelVasoconstrictor AgentsVasodilator Agentshypertensionkynureninelarge-conductance calcium-activated potassium channelspre-eclampsiapregnancytryptophan
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.