Evidence map›Paper›PMID 33656287›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2021

Investigating the association between cancer and the risk of dementia: Results from the Memento cohort.

Jonviea D Chamberlain, Anaïs Rouanet, Bruno Dubois, Florence Pasquier, Olivier Hanon, Audrey Gabelle, Mathieu Ceccaldi, Pierre Krolak-Salmon, Yannick Béjot, Olivier Godefroy and 5 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Differential dementia detection from multimodal brain images in a real-world dataset.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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  15. Investigating the association between cancer and the risk of dementia: Results from the Memento cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jonviea D ChamberlainBordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France.ORCID 0000-0002-9515-1076
Anaïs RouanetBordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France.
Bruno DuboisSorbonne Université, AP-HP, Hôpital de la Pitié-Salpêtrière, Boulevard de l'hôpital, Paris, France.
Florence PasquierInserm UMR-S 1172, CHU Lille, Labex DISTALZ, LiCEND, Lille, France.
Olivier HanonEA 4468, Université de Paris, Geriatric department Broca hospital, APHP, Paris, France.
Audrey GabelleCentre Mémoire Ressources Recherche Département de Neurologie CHU Gui de Chauliac, Montpellier, France.
Mathieu CeccaldiOuest CHU Timone APHM & Aix Marseille Univ INSERM INS Inst Neurosci Syst, CMMR PACA, Marseille, France.
Pierre Krolak-SalmonHospices Civils de Lyon, Inserm 1048, CNRS 5292, Lyon University, Lyon, France.
Yannick BéjotDepartment of Neurology and Memory Resource and Research Center of Dijon, EA7460, University Hospital of Dijon, University of Burgundy, Dijon, France.
Olivier GodefroyNeurology Department, Amiens University Hospital, Amiens, France.
David WallonFunctional Neurosciences Lab (UR UPJV4559), Centre Universitaire de Recherche en Santé, Normandie Univ, UNIROUEN, Department of Neurology and CNR-MAJ, Inserm U1245 and Rouen University Hospital, Rouen, France.
Armelle GentricCMRR CHU de Brest, Brest, France.
Geneviève ChêneCIC1401-EC, Inserm, Bordeaux, France.
Carole DufouilCIC1401-EC, Inserm, Bordeaux, France.
Memento Study group

Funding

Medical Research Council MR/L023784/2
6 · The paper itself

Abstract

introductionStudies on the association of cancer and risk of dementia are inconclusive due to result heterogeneity and concerns of survivor bias and unmeasured confounding.

methodsThis study uses data from the Memento cohort, a French multicenter cohort following persons with either mild or isolated cognitive complaints for a median of 5 years. Illness-death models (IDMs) were used to estimate transition-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for incident cancer in relation to dementia from time since study entry.

resultsThe analytical sample (N = 2258) excluded 65 individuals without follow-up information. At the end of follow-up, 286 individuals were diagnosed with dementia, 166 with incident cancer, and 95 died. Incident cancer was associated with a reduced risk of dementia (HR = 0.58, 95% CI = 0.35-0.97), with a corresponding E-value of 2.84 (lower CI = 1.21). DISCUSSION: This study supports a protective relationship between incident cancer and dementia, encouraging further investigations to understand potential underlying mechanisms.

Indexed as

Cognitive DysfunctionAgedCohort StudiesDementiaFemaleFranceHumansMaleMortalityNeoplasmsNeuropsychological TestsAlzheimer's diseasecancerdementiaepidemiologyillness-death modelselection bias

Identifiers

PMID33656287
PMCPMC8518910

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.