ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2021
Early life stress in mice alters gut microbiota independent of maternal microbiota inheritance.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 33 citations in OpenAlex.
- Early life stress blunts time-of-day-specific autonomic function in adult male mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- RNA in Plasma Extracellular Vesicles of Adolescent Rhesus Macaques Reveals Immune, Bioenergetic, and Microbial Imprints of Early-Life Adversity: An Exploratory Analysis.Biological psychiatry · 2026Article
- Maternal separation-induced changes in breast milk fatty acid composition are associated with altered gut microbiota and serotonergic gene expression in neonatal mice.Molecular biomedicine · 2026Article
- Prucalopride, a serotonin type 4 receptor agonist, induces fast anxiolytic/antidepressant effects and concomitant changes in the gut microbiota.NPJ biofilms and microbiomes · 2026Article
- Impact of Sex, Gonadectomy, and Repeated Restraint Stress on Gut Microbiome in Mice.Molecular neurobiology · 2025Article
- Evidence of postnatal neglect-dependent resiliency in thymic, gut, and behavioral outcomes in a mouse model of early life stress.Brain, behavior, and immunity · 2025Article
- The impact of perinatal maternal stress on the maternal and infant gut and human milk microbiomes: A scoping review.PloS one · 2025Article
- Influence of reef habitat on coral microbial associations.Environmental microbiology reports · 2024Article
- Transgenerational effects of early life stress on the fecal microbiota in mice.Communications biology · 2024Article
- The strength of gut microbiota transfer along social networks and genealogical lineages in the house mouse.FEMS microbiology ecology · 2024Article
- Comparative characterization of the infant gut microbiome and their maternal lineage by a multi-omics approach.Nature communications · 2024Article
- Effect of a multi-strain probiotic mixture consumption on anxiety and depression symptoms induced in adult mice by postnatal maternal separation.Microbiome · 2024Article
- Probiotics' effects on gut microbiota in jaundiced neonates: a randomized controlled trial protocol.Frontiers in pediatrics · 2024Article
- Microbiome-driven alterations in metabolic pathways and impaired cognition in aged female TgF344-AD rats.Aging brain · 2024Article
- Article
- Chronic early life stress alters the neuroimmune profile and functioning of the developing zebrafish gut.Brain, behavior, & immunity - health · 2023Article
- Early life exposure to broccoli sprouts confers stronger protection against enterocolitis development in an immunological mouse model of inflammatory bowel disease.bioRxiv : the preprint server for biology · 2023Article
- Early Life Stress in Mice Leads to Impaired Colonic Corticosterone Production and Prolonged Inflammation Following Induction of Colitis.Inflammatory bowel diseases · 2023Article
- Multiomics profiling of the impact of an angiotensin (1-7)-expressing probiotic combined with exercise training in aged male rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Arresting microbiome development limits immune system maturation and resistance to infection in mice.Cell host & microbe · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Exposure to early life stress (ELS) is associated with a greater risk of chronic disease development including depression and cardiovascular disease. Altered gut microbiota has been linked to both depression and cardiovascular disease in mice and humans. Rodent models of early life neglect are used to characterize the mechanistic links between early life stress (ELS) and the risk of disease later in life. However, little is understood about ELS exposure and the gut microbiota in the young mice and the influence of the maternal inheritance of the gut microbiota. We used a mouse model of ELS, maternal separation with early weaning (MSEW), and normally reared mice to determine whether the neonate microbiota is altered, and if so, are the differences attributable to changes in dam microbiota that are then transmitted to their offspring. Individual amplicon sequence variants (ASVs) displayed differential abundance in the microbiota of MSEW compared with normally reared pups at
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.