Evidence map›Paper›PMID 33655720›Full record

ReviewKorean circulation journal2021

Ethnic Difference of Thrombogenicity in Patients with Cardiovascular Disease: a Pandora Box to Explain Prognostic Differences.

Hyun Kuk Kim, Udaya S Tantry, Hyun Woong Park, Eun Seok Shin, Tobias Geisler, Diana A Gorog, Paul A Gurbel, Young Hoon Jeong

Open access · greenAbstract readReview
In one paragraph

Review in Korean circulation journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Oral Anticoagulation Monotherapy vs Dual-Pathway Antithrombotic Therapy in Chronic Coronary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Pooled it
  3. Review
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  5. Article
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  7. Article
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  9. Edoxaban Monotherapy and Incidence of Transcatheter Heart Valve Leaflet Thrombosis - The Rotterdam Edoxaban (REDOX) Study.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025
    Article
  10. Article
  11. Article
  12. Surgical Outcomes and Sociodemographic Disparities Across All Races: An ACS-NSQIP and NHIS Multi-Institutional Analysis of Over 7.5 Million Patients.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2024
    Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 4 countries.

Hyun Kuk KimDepartment of Cardiology, Chosun University Hospital, Gwangju, Korea.ORCID https://orcid.org/0000-0002-4554-041X
Udaya S TantrySinai Center for Thrombosis Research, Sinai Hospital of Baltimore, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-8542-8596
Hyun Woong ParkDepartment of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea.ORCID https://orcid.org/0000-0002-2025-7781
Eun Seok ShinDivision of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
Tobias GeislerDepartment of Cardiology and Angiology, University Hospital of Tübingen, Tübingen, Germany.
Diana A GorogNational Heart and Lung Institute, Imperial College, London, United Kingdom.ORCID https://orcid.org/0000-0002-9286-1451
Paul A GurbelSinai Center for Thrombosis Research, Sinai Hospital of Baltimore, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-5461-568X
Young Hoon JeongDepartment of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea.ORCID https://orcid.org/0000-0003-0403-3726
Sinai Hospital · USChangwon National University · KRChosun University Hospital · KRGyeongsang National University · KRUlsan College · KRUniversity Children's Hospital Tübingen · DEUniversity of Hertfordshire · GB

Funding

National Research Foundation of Korea NRF-2015R1A5A2008833
6 · The paper itself

Abstract

Arterial and venous atherothrombotic events are finely regulated processes involving a complex interplay between vulnerable blood, vulnerable vessel, and blood stasis. Vulnerable blood ('thrombogenicity') comprises complex interactions between cellular components and plasma factors (inflammatory, procoagulant, anticoagulant, and fibrinolytic factors). The extent of thrombogenicity may determine the progression of atheroma and the clinical manifestation of atherothrombotic events, with the highest thrombogenicity in African Americans and lowest in East Asians. Inherent thrombogenicity may influence clinical efficacy and safety of specific antithrombotic treatments in high-risk patients, which may in part explain the observation that East Asian patients have reduced anti-ischemic benefits and elevated bleeding risk with antithrombotic therapy compared to Caucasian patients. In this review, we discuss available evidence regarding the racial differences in thrombogenicity and its impact on clinical outcomes among patients with atherosclerotic cardiovascular disease.

Indexed as

Antithrombotic treatmentCoagulationInflammationRaceThrombogenicity

Identifiers

PMID33655720
PMCPMC7925962
OpenAlexW3130532548

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.