ArticleBrain and behavior2021
Modifiable risk factors for epilepsy: A two-sample Mendelian randomization study.
Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 5 of them syntheses that pooled it.
What it found
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Who cites it
24 citing papers in PubMed, 5 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Vitamin D and human health: evidence from Mendelian randomization studies.European journal of epidemiology · 2024Pooled it
- Exploring the Smoking-Epilepsy Nexus: a systematic review and meta-analysis of observational studies : Smoking and epilepsy.BMC medicine · 2024Pooled it
- Alcohol consumption and its association with cancer, cardiovascular, liver and brain diseases: a systematic review of Mendelian randomization studies.Frontiers in epidemiology · 2024Pooled it
- Causal effect of psychiatric disorders on epilepsy: A two-sample Mendelian randomization study.Brain and behavior · 2023Pooled it
- Assessing the causal association between human blood metabolites and the risk of epilepsy.Journal of translational medicine · 2022Pooled it
- In Vivo Longitudinal Mapping of Brain Iron Accumulation After Pilocarpine-Induced Status Epilepticus.Molecular neurobiology · 2026Article
- Multiomic insights into the MPO-mediated NET formation pathway in alcohol-induced epilepsy risk.Genes & diseases · 2026Article
- Therapeutic effects of curcumin on seizure and its mechanisms of action.Inflammopharmacology · 2026Review
- Cerebrospinal fluid metabolites as potential biomarkers for epilepsy: Insights from genome-wide association studies.Epilepsia open · 2025Article
- Exploring the Therapeutic Potential of Baicalin: Mitigating Anxiety and Depression in Epileptic Rats.Combinatorial chemistry & high throughput screening · 2025Article
- The association between active and passive tobacco smoke exposures and epilepsy in United States participants of the National Health and Nutrition Examination Survey (2013-2018).Frontiers in neurology · 2025Article
- Causal Relationships Between Epilepsy, Anti-Epileptic Drugs, and Serum Vitamin D and Vitamin D Binding Protein: A Bidirectional and Drug Target Mendelian Randomization Study.CNS neuroscience & therapeutics · 2024Article
- Psychiatric comorbidities in epilepsy: population co-occurrence, genetic correlations and causal effects.General psychiatry · 2024Article
- Potential causal association of diabetes mellitus and blood glucose related indexes with the onset of epilepsy: a two-sample Mendelian randomization study.Frontiers in neurology · 2024Article
- Causal associations of ischemic stroke, metabolic factors, and related medications with epilepsy: a Mendelian randomization study.Frontiers in neurology · 2024Article
- Causal relationship between telomere length and epilepsy: A bidirectional Mendelian randomization study.Epilepsia open · 2023Observational
- Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- Using Mendelian Randomization to Study the Role of Iron in Health and Disease.International journal of molecular sciences · 2023Review
- Signaling pathway mechanisms of neurological diseases induced by G protein-coupled receptor 39.CNS neuroscience & therapeutics · 2023Review
- Roles of gut microbiome in epilepsy risk: A Mendelian randomization study.Frontiers in microbiology · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWe conducted a two-sample Mendelian randomization study to determine the associations of modifiable risk factors with epilepsy.
methodsFourteen potential risk factors for epilepsy were selected based on a systematic review of risk factors for epilepsy. Single-nucleotide polymorphisms associated with each exposure at the genome-wide significance threshold (p < 5×10
resultsAmong 14 potential risk factors, 4 showed significant associations with epilepsy in FinnGen. All associations were directionally similar in UK Biobank and associated with epilepsy at p ≤ .004 in meta-analyses of FinnGen and UK Biobank data. The odds ratios of epilepsy were 1.46 (95% CI, 1.18, 1.82) for one unit increase in log odds ratio of having depression, 1.44 (95% CI, 1.13, 1.85) for one standard deviation increase in serum ferritin, 1.12 (95% CI, 1.04, 1.21) for one standard deviation increase in transferrin saturation, and 1.25 (95% CI, 1.09, 1.43) for one standard deviation increase in the prevalence of smoking initiation. There were suggestive associations of serum iron and magnesium with epilepsy. No association was observed for insomnia, blood pressure, alcohol consumption, or serum vitamin B12, 25-hydroxyvitamin D and calcium levels.
conclusionThis MR study identified several modifiable risk factors for adulthood epilepsy. Reducing prevalence of depression and smoking initiation should be considered as primary prevention strategies for epilepsy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.