Evidence map›Paper›PMID 33655519›Full record

ArticleAllergy2021

COVID-19 pandemic and allergen immunotherapy-an EAACI survey.

Oliver Pfaar, Ioana Agache, Matteo Bonini, Helen Annaruth Brough, Tomás Chivato, Stefano R Del Giacco, Radoslaw Gawlik, Aslı Gelincik, Karin Hoffmann-Sommergruber, Marek Jutel and 22 more

Open access · bronzeAbstract read
In one paragraph

Article in Allergy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Allergic diseases and immunodeficiencies in children, lessons learnt from COVID-19 pandemic by 2022: A statement from the EAACI-section on pediatrics.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022
    Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Real-life report of allergen immunotherapy management during the COVID-19 outbreak in France and Spain.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 20 institutions in 15 countries.

Oliver PfaarDepartment of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.ORCID 0000-0003-4374-9639
Ioana AgacheTransylvania University, Brasov, Romania.ORCID 0000-0001-7994-364X
Matteo BoniniDepartment of Cardiovascular and Thoracic Sciences, Fondazione Policlinico Universitario A. Gemelli - IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.ORCID 0000-0002-3042-0765
Helen Annaruth BroughChildren's Allergy Service, Evelina Children's Hospital, Guy's and St, Thomas, Hospital NHS Foundation Trust, London, UK.ORCID 0000-0001-7203-0813
Tomás ChivatoSchool of Medicine, University CEU San Pablo Madrid, Spain.
Stefano R Del GiaccoDepartment of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.ORCID 0000-0002-4517-1749
Radoslaw GawlikDepartment of Internal Medicine, Allergology, Clinical Immunology, Medical University of Silesia, Katowice, Poland.
Aslı GelincikDepartment of Internal Medicine, Division of Immunology and Allergic Diseases, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.ORCID 0000-0002-3524-9952
Karin Hoffmann-SommergruberInstitute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-8830-058X
Marek JutelDepartment of Clinical Immunology, Wrocław Medical University, Wroclaw, Poland.
Ludger KlimekCenter for Rhinology and Allergology, Wiesbaden, Germany.ORCID 0000-0002-2455-0192
Edward F KnolDepartments of Immunology and Dermatology/Allergology, University Medical Center Utrecht, Utrecht, The Netherlands.
Antti LauermaDepartment of Dermatology and Allergology, Helsinki University Hospital Inflammation Centre, University of Helsinki, Helsinki, Finland.
Markus OllertDepartment of Dermatology and Allergy Centre, Odense Research Centre for Anaphylaxis (ORCA), Odense University Hospital, University of Southern Denmark, Odense, Denmark.ORCID 0000-0002-8055-0103
Liam O'MahonyDepartments of Medicine and Microbiology, APC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID 0000-0003-4705-3583
Charlotte G MortzDepartment of Dermatology and Allergy Centre, Odense Research Centre for Anaphylaxis (ORCA), Odense University Hospital, University of Southern Denmark, Odense, Denmark.ORCID 0000-0001-8710-0829
Oscar PalomaresDepartment of Biochemistry and Molecular Biology, Chemistry School, Complutense University of Madrid, Madrid, Spain.ORCID 0000-0003-4516-0369
Carmen RiggioniAllergy and Clinical Immunology, Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.ORCID 0000-0002-8745-0228
Jürgen SchwarzeCentre for Inflammation Research and Child Life and Heath, the University of Edinburgh, Edinburgh, UK.
Isabel SkypalaNational Heart and Lung Institute (NHLI), Imperial College London, London, UK.ORCID 0000-0003-3629-4293
María José TorresAllergy Unit, Malaga Regional University Hospital-UMA-ARADyAL, Málaga, Spain.ORCID 0000-0001-5228-471X
Eva UntersmayrInstitute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-1963-499X
Jolanta Walusiak-SkorupaDepartment of Occupational Diseases and Environmental Health, Nofer Institute of Occupational Medicine, Lodz, Poland.
Adam ChakerDepartment of Otolaryngology and Center of Allergy and Environment, TUM School of Medicine, Technical University of Munich, Munich, Germany.
Mattia GiovanniniAllergy Unit, Department of Pediatrics, Meyer Children's University Hospital, Florence, Italy.ORCID 0000-0001-9568-6882
Enrico HefflerPersonalized Medicine, Asthma and Allergy - Humanitas Clinical and Research Hospital IRCCS, Rozzano, MI, Italy.ORCID 0000-0002-0492-5663
Erika Jensen-JarolimInstitute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-4019-5765
Cristina Quecchia"Io e l'Asma" Center, Children's Hospital, ASST Spedali Civili, Brescia, Italy.
Mónica Sandoval-RuballosInstitut de Recerca Sant Joan de Déu, Barcelona, Spain.ORCID 0000-0002-8747-4799
Umit SahinerDepartment of Pediatric Allergy, Hacettepe University School of Medicine, Ankara, Turkey.ORCID 0000-0003-0088-913X
Vesna Tomić SpirićFaculty of Medicine, University of Belgrade, Belgrade, Serbia.
Montserrat Alvaro-LozanoInstitut de Recerca Sant Joan de Déu, Barcelona, Spain.ORCID 0000-0002-5528-8043
Hospital Sant Joan de Déu Barcelona · ESMedical University of Vienna · ATUniversity of Southern Denmark · DKAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITCentre for Inflammation Research · GBHacettepe University · TRHospital Regional Universitario de Málaga · ESHumanitas University · ITIstanbul University · TRMedical University of Silesia · PLMeyer Children's Hospital · ITNational University of Singapore · SGNofer Institute of Occupational Medicine · PLPhilipps University of Marburg · DERoyal Brompton & Harefield NHS Foundation Trust · GBSt Thomas' Hospital · GBTechnical University of Munich · DETransylvania University of Brașov · ROUniversidad Complutense de Madrid · ESUniversidad San Pablo CEU · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAs in many fields of medical care, the coronavirus disease 2019 (COVID-19) resulted in an increased uncertainty regarding the safety of allergen immunotherapy (AIT). Therefore, the European Academy of Allergy and Clinical Immunology (EAACI) aimed to analyze the situation in different countries and to systematically collect all information available regarding tolerability and possible amendments in daily practice of sublingual AIT (SLIT), subcutaneous AIT (SCIT) for inhalant allergies and venom AIT.

methodsUnder the framework of the EAACI, a panel of experts in the field of AIT coordinated by the Immunotherapy Interest Group set-up a web-based retrospective survey (SurveyMonkey

results417 respondents providing AIT to their patients in daily routine answered the survey. For patients (without any current symptoms to suspect COVID-19), 60% of the respondents informed of not having initiated SCIT (40% venom AIT, 35% SLIT) whereas for the maintenance phase of AIT, SCIT was performed by 75% of the respondents (74% venom AIT, 89% SLIT). No tolerability concern arises from this preliminary analysis. 16 physicians reported having performed AIT despite (early) symptoms of COVID-19 and/or a positive test result for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

conclusionsThis first international retrospective survey in atopic diseases investigated practical aspects and tolerability of AIT during the COVID-19 pandemic and gave no concerns regarding reduced tolerability under real-life circumstances. However, the data indicate an undertreatment of AIT, which may be temporary, but could have a long-lasting negative impact on the clinical care of allergic patients.

Indexed as

COVID-19PandemicsDesensitization, ImmunologicHumansRetrospective StudiesSARS-CoV-2Surveys and Questionnairesallergen immunotherapy (AIT)COVID-19pandemicSARS-CoV-2survey

Identifiers

PMID33655519
PMCPMC8013670
OpenAlexW3134746977

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.