Evidence map›Paper›PMID 33655478›Full record

ReviewEnvironmental science and pollution research international2021

Epimutational effects of electronic cigarettes.

Rui Yan, Xu-Li Chen, Yan-Ming Xu, Andy T Y Lau

Abstract readReview
PubMed Publisher
In one paragraph

Review in Environmental science and pollution research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Epigenomic Dysregulation in Youth Vapers: Implications for Disease Risk Assessment.American journal of respiratory cell and molecular biology · 2025
    Article
  2. Review
  3. Review
  4. Review
  5. Epigenetic effects of herbal medicine.Clinical epigenetics · 2023
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rui Yan *Laboratory of Cancer Biology and Epigenetics, Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, Guangdong, 515041, People's Republic of China.ORCID https://orcid.org/0000-0002-2217-3979
Xu-Li Chen *Laboratory of Cancer Biology and Epigenetics, Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, Guangdong, 515041, People's Republic of China.ORCID https://orcid.org/0000-0002-6013-2190
Yan-Ming XuLaboratory of Cancer Biology and Epigenetics, Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, Guangdong, 515041, People's Republic of China. amyymxu@stu.edu.cn.ORCID https://orcid.org/0000-0003-1124-0045
Andy T Y LauLaboratory of Cancer Biology and Epigenetics, Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, Guangdong, 515041, People's Republic of China. andytylau@stu.edu.cn.ORCID http://orcid.org/0000-0002-7146-7789
Shantou University · CN

Funding

Basic and Applied Research Major Projects of Guangdong Province of China 2017KZDXM035Basic and Applied Research Major Projects of Guangdong Province of China 2018KZDXM036National Natural Science Foundation of China 31271445National Natural Science Foundation of China 31771582Natural Science Foundation of Guangdong Province 2017A030313131"Yang Fan" Project of Guangdong Province of China Andy T. Y. Lau-2016"Yang Fan" Project of Guangdong Province of China Yan-Ming Xu-2015
6 · The paper itself

Abstract

Electronic cigarettes (e-cigarettes), since they do not require tobacco combustion, have traditionally been considered less harmful than conventional cigarettes (c-cigarettes). In recent years, however, researchers have found many toxic compounds in the aerosols of e-cigarettes, and numerous studies have shown that e-cigarettes can adversely affect the human epigenome. In this review, we provide an update on recent findings regarding epigenetic outcomes of e-cigarette aerosols. Moreover, we discussed the effects of several typical e-cigarette ingredients (nicotine, tobacco-specific nitrosamines, volatile organic compounds, carbonyl compounds, and toxic metals) on DNA methylation, histone modifications, and noncoding RNA expression. These epigenetic effects could explain some of the diseases caused by e-cigarettes. It also reminds the public that like c-cigarettes, inhaling e-cigarette aerosols could also be accompanied with potential epigenotoxicity on the human body.

Indexed as

Electronic Nicotine Delivery SystemsNitrosaminesTobacco ProductsAerosolsHumansNicotineAerosolsNicotineNitrosaminesDNA methylationElectronic cigarettesEpigeneticsHistone modificationsncRNA

Identifiers

PMID33655478
OpenAlexW3135908998

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.