SynthesisSurgical endoscopy2021
Is peroral endoscopic myotomy (POEM) more effective than pneumatic dilation and Heller myotomy? A systematic review and meta-analysis.
Synthesis in Surgical endoscopy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 5 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Comprehensive evaluation of current strategies in achalasia treatment: Insights from an umbrella review.Medicine · 2025Pooled it
- Long-term outcomes after per-oral endoscopic myotomy versus laparoscopic Heller myotomy in the treatment of achalasia: a systematic review and meta-analysis.Surgical endoscopy · 2025Pooled it
- 2024 Update to SAGES guidelines for the use of peroral endoscopic myotomy (POEM) in the treatment of achalasia.Surgical endoscopy · 2025Guideline
- Achalasia: laparoscopic Heller myotomy with fundoplication versus peroral endoscopic myotomy-a systematic review and meta-analysis.Esophagus : official journal of the Japan Esophageal Society · 2024Pooled it
- SAGES guidelines for the use of peroral endoscopic myotomy (POEM) for the treatment of achalasia.Surgical endoscopy · 2021Guideline
- Predicting success after laparoscopic heller myotomy: lessons from 22 years in a resource-limited context.Langenbeck's archives of surgery · 2026Article
- Surgical and endoscopic interventions in the management of idiopathic achalasia.The Cochrane database of systematic reviews · 2025Article
- The SAGES MASTERS Program: top 10 seminal articles for Heller myotomy and treatment of achalasia.Surgical endoscopy · 2025Review
- Limited hiatal dissection versus Dor-fundoplication in laparoscopic Heller myotomy for achalasia: First experience in Morocco - A case control comparison study.International journal of surgery case reports · 2025Article
- North American Expert Consensus on the Post-procedural Care of Patients After Per-oral Endoscopic Myotomy Using a Delphi Process.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2025Article
- Review
- One anastomosis gastric bypass as a primary bariatric surgery: MBSAQIP database analysis of short-term safety and outcomes.Surgical endoscopy · 2024Article
- Review
- Do preoperative endoscopic interventions predict symptom recurrence or reintervention after peroral endoscopic myotomy?Surgical endoscopy · 2023Article
- Socioeconomic disparities in the utilization of primary robotic hernia repair.Surgical endoscopy · 2023Article
- Probability of additional intervention and long-term follow-up of esophagomyotomy.Surgical endoscopy · 2023Article
- Superselective arterial microcoil embolization for delayed bleeding after peroral endoscopic myotomy.The Journal of international medical research · 2022Article
- Review
- Peroral Endoscopic Myotomy for Achalasia.World journal of surgery · 2022Review
- Modified Peroral Endoscopic Myotomy Technique for Type II Achalasia: A Multicenter Retrospective Study.Gastroenterology research and practice · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAchalasia is a rare, chronic, and morbid condition with evolving treatment. Peroral endoscopic myotomy (POEM) has gained considerable popularity, but its comparative effectiveness is uncertain. We aim to evaluate the literature comparing POEM to Heller myotomy (HM) and pneumatic dilation (PD) for the treatment of achalasia.
methodsWe conducted a systematic review of comparative studies between POEM and HM or PD. A priori outcomes pertained to efficacy, perioperative metrics, and safety. Internal validity of observational studies and randomized trials (RCTs) was judged using the Newcastle Ottawa Scale and the Cochrane Risk of Bias 2.0 tool, respectively.
resultsFrom 1379 unique literature citations, we included 28 studies comparing POEM and HM (n = 21) or PD (n = 8), with only 1 RCT addressing each. Aside from two 4-year observational studies, POEM follow-up averaged ≤ 2 years. While POEM had similar efficacy to HM, POEM treated dysphagia better than PD both in an RCT (treatment "success" RR 1.71, 95% CI 1.34-2.17; 126 patients) and in observational studies (Eckardt score MD - 0.43, 95% CI - 0.71 to - 0.16; 5 studies; I
conclusionsPOEM has similar outcomes to HM and greater efficacy than PD. Reflux remains a critical outcome with unknown long-term clinical significance due to insufficient data and inconsistent reporting.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.