Trial reportArchives of women's mental health2021
Comparing the effectiveness of home visiting paraprofessionals and mental health professionals delivering a postpartum depression preventive intervention: a cluster-randomized non-inferiority clinical trial.
Trial report in Archives of women's mental health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02979444 (Comparing the Effectiveness of Clinicians and Paraprofessionals to Reduce Disparities in Perinatal Depression), which is not on this map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparing the Effectiveness of Clinicians and Paraprofessionals to Reduce Disparities in Perinatal Depression
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Proactive approaches to preventing postpartum depression in non-depressive pregnant women: a comprehensive scoping review.Frontiers in global women's health · 2025Pooled it
- A systematic review of community-based interventions to address perinatal mental health.Seminars in perinatology · 2024Pooled it
- Can psychological interventions prevent or reduce risk for perinatal anxiety disorders? A systematic review and meta-analysis.General hospital psychiatryPooled it
- Effects of a Personalized Stress Management Intervention on Maternal Mental Health: A Randomized Clinical Trial.Archives of women's mental health · 2025Trial
- Acceptability and appropriateness of a perinatal depression preventive group intervention: a qualitative analysis.BMC health services research · 2020Trial
- Caresses and coos: Examining long-term effects of a perinatal depression preventive intervention on parental warmth.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2026Article
- Perinatal mental health screening and care among those with pregnancy complications.American journal of obstetrics & gynecology MFM · 2026Review
- Caregiver Adverse Childhood Experiences, Resilience, and Mental Health in a Predominantly Hispanic Pediatric Clinic Setting.Journal of child & adolescent trauma · 2026Article
- Effects of a postpartum depression intervention: subgroup analyses from a cluster randomized trial.Frontiers in psychiatry · 2026Article
- Integrating a Brief Behavioral Intervention Into Case Management for Mothers With Perinatal Substance Use Disorder: Nonrandomized Pilot Feasibility Study.JMIR formative research · 2025Article
- Maternal PTSD symptoms and sensitivity during caregiving in early postpartum: The moderating role of resting and reactive RSA in a trauma-exposed sample.Psychological medicine · 2025Article
- Unplanned pregnancy and perinatal depression: secondary exploratory analyses from a racially and ethnically diverse, low-income sample of birthing people in the United States.BMC pregnancy and childbirth · 2025Article
- Training Paraprofessionals to Implement Hold Me Tight in South Africa: Outcomes and Experiences.Journal of marital and family therapy · 2025Article
- A Community-Based Intervention for Mental Health and Wellbeing in Pregnancy and Postpartum: One Healthy Start Site's Story.International journal of women's health · 2025Article
- Developing a coaching manual to provide human support for the Mothers and Babies Online (eMB) perinatal mental health intervention.Internet interventions · 2024Article
- Acceptability and Utility of a Digital Group Intervention to Prevent Perinatal Depression in Youths via Interactive Maternal Group for Information and Emotional Support (IMAGINE): Pilot Cohort Study.JMIR formative research · 2024Article
- Race, ethnicity, and considerations for data collection and analysis in research studies.Journal of clinical and translational science · 2024Review
- Cultural Adaptation of the Mothers and Babies Intervention for Use in Tribal Communities.Frontiers in psychiatry · 2022Article
- Leading the charge toward a world without depression: perinatal depression can be prevented.Archives of women's mental health · 2021Review
- Testing the effects of a prenatal depression preventive intervention on parenting and young children's self-regulation and functioning (EPIC): protocol for a longitudinal observational study.BMC public health · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine whether pregnant women receiving the Mothers and Babies group-based intervention exhibited greater depressive symptom reductions and fewer new cases of major depression than women receiving usual community-based services, and to examine whether groups run by paraprofessional home visitors and mental health professionals yielded similar depressive symptom reductions and prevention of major depression. Using a cluster-randomized design, 37 home visiting programs were randomized to usual home visiting, Mothers and Babies delivered via home visiting paraprofessionals, or Mothers and Babies delivered via mental health professionals. Baseline assessments were conducted prenatally with follow-up extending to 24 weeks postpartum. Eligibility criteria were ≥ 16 years old, ≤ 33 gestation upon referral, and Spanish/English speaking. Depressive symptoms at 24 weeks postpartum was the primary outcome. Eight hundred seventy-four women were enrolled. Neither intervention arm was superior to usual care in decreasing depressive symptoms across the sample (p = 0.401 home visiting paraprofessional vs. control; p = 0.430 mental health professional vs. control). Post hoc analyses suggest a positive intervention effect for women exhibiting mild depressive symptoms at baseline. We have evidence of non-inferiority, as the model-estimated mean difference in depressive symptoms between intervention arms (0.01 points, 95% CI: -0.79, 0.78) did not surpass our pre-specified margin of non-inferiority of two points. Although we did not find statistically significant differences between intervention and control arms, non-inferiority analyses found paraprofessional home visitors generated similar reductions in depressive symptoms as mental health professionals. Additionally, Mothers and Babies appears to reduce depressive symptoms among women with mild depressive symptoms when delivered by mental health professionals. This trial is registered on ClinicalTrials.gov (initial post: December 1, 2016; identifier: NCT02979444).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.