Evidence map›Paper›PMID 33655416›Full record

Trial reportInternational journal of hematology2021

Autologous hematopoietic cell transplantation following high-dose cytarabine consolidation for core-binding factor-acute myeloid leukemia in first complete remission: a phase 2 prospective trial.

Eun-Ji Choi, Je-Hwan Lee, Hawk Kim, Yunsuk Choi, Won-Sik Lee, Sang-Min Lee, Jun-Hong Park, Han-Seung Park, Jung-Hee Lee, Kyoo-Hyung Lee and 1 more

Abstract readClinical Trial, Phase IIMulticenter Study
PubMed Publisher
In one paragraph

Trial report in International journal of hematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Eun-Ji ChoiDepartment of Hematology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
Je-Hwan LeeDepartment of Hematology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea. jhlee3@amc.seoul.kr.ORCID http://orcid.org/0000-0002-7060-1675
Hawk KimDivision of Hematology, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.
Yunsuk ChoiDepartment of Hematology and Oncology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
Won-Sik LeeDepartment of Hematology and Oncology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
Sang-Min LeeDepartment of Hematology and Oncology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
Jun-Hong ParkDepartment of Hematology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
Han-Seung ParkDepartment of Hematology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
Jung-Hee LeeDepartment of Hematology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
Kyoo-Hyung LeeDepartment of Hematology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
CoOperative Study Group A for Hematology (COSAH)
Ulsan College · KRInje University Busan Paik Hospital · KR

Funding

Asan Institute for Life Sciences, Asan Medical Center 2016-199
6 · The paper itself

Abstract

Core-binding factor (CBF)-acute myeloid leukemia (AML) generally have a favorable prognosis. However, approximately 50% of patients experience disease relapse during or after post-remission therapy. Retrospective studies on autologous hematopoietic cell transplantation (AHCT) have shown improved survival with decreased relapse rate in CBF-AML. In this prospective study, we evaluate the outcomes of AHCT following high-dose cytarabine (HiDAC) consolidation in patients with CBF-AML in first complete remission (CR). Adult patients with CBF-AML achieving first CR after induction chemotherapy were eligible for the study. High-dose chemotherapy before AHCT included intravenous busulfan (3.2 mg/kg/day, days - 7 to - 5) and etoposide (400 mg/m

Indexed as

Consolidation ChemotherapyCore Binding FactorsHematopoietic Stem Cell TransplantationLeukemia, Myeloid, AcuteNeoplasm ProteinsAdultAutograftsChromosome AberrationsChromosomes, HumanCytarabineDisease-Free SurvivalFemaleHumansMaleMiddle AgedRemission InductionCore Binding FactorsCytarabineNeoplasm ProteinsAcute myeloid leukemiaAutologous hematopoietic cell transplantationCore-binding factor

Identifiers

PMID33655416
OpenAlexW3134104327

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.