Evidence map›Paper›PMID 33655376›Full record

ArticleCerebellum (London, England)2021

Altered Cerebro-Cerebellar Dynamic Functional Connectivity in Alcohol Use Disorder: a Resting-State fMRI Study.

Majd Abdallah, Natalie M Zahr, Manojkumar Saranathan, Nicolas Honnorat, Nicolas Farrugia, Adolf Pfefferbaum, Edith V Sullivan, Sandra Chanraud

Open access · greenAbstract read
In one paragraph

Article in Cerebellum (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Majd AbdallahAquitaine Institute of Cognitive and Integrative Neuroscience, UMR CNRS 5287, University of Bordeaux, Bordeaux, France.
Natalie M ZahrDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94305-5723, USA.
Manojkumar SaranathanDepartment of Medical Imaging, University of Arizona, Tucson, AZ, USA.
Nicolas HonnoratDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94305-5723, USA.
Nicolas FarrugiaLab STICC, UMR CNRS 6285, IMT Atlantique, Brest, France.
Adolf PfefferbaumDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94305-5723, USA.
Edith V SullivanDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94305-5723, USA.
Sandra ChanraudAquitaine Institute of Cognitive and Integrative Neuroscience, UMR CNRS 5287, University of Bordeaux, Bordeaux, France. sandra.chanraud@u-bordeaux.fr.ORCID http://orcid.org/0000-0002-4299-3050
SRI International · USCentre National de la Recherche Scientifique · FRUniversity of Arizona · US

Funding

CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISMR01AA005965 · NIAAA · STANFORD UNIVERSITY · PI PFEFFERBAUM, ADOLF, ZAHR, NATALIE M · 1985 to 2025
$13.0M
CEREBELLAR STRUCTURE AND FUNCTION IN ALCOHOLISMR01AA010723 · NIAAA · STANFORD UNIVERSITY · PI SULLIVAN, EDITH VIONI, ZAHR, NATALIE M · 1996 to 2025
$8.3M
Cerebellar Structure and Function in AlcoholismR37AA010723 · NIAAA · STANFORD UNIVERSITY · PI SULLIVAN, EDITH VIONI · 2010 to 2019
$5.4M
US-France Research Collaboration on Neuroimaging Studies of AlcoholismU01AA017923 · NIAAA · STANFORD UNIVERSITY · PI PFEFFERBAUM, ADOLF, SULLIVAN, EDITH VIONI · 2008 to 2017
$2.4M
Substructural Volumetry of Hippocampus and Thalamus in AlcoholismR21AA023582 · NIAAA · SRI INTERNATIONAL · PI SARANATHAN, MANOJKUMAR, ZAHR, NATALIE M · 2015 to 2016
$502k
International Research Collaboration on Neuroimaging Studies of AlcoholismR01AA017923 · NIAAA · STANFORD UNIVERSITY · PI PFEFFERBAUM, ADOLF, SULLIVAN, EDITH VIONI · 2018 to 2019
$496k
NIAAA NIH HHS AA010723NIAAA NIH HHS AA017923NIAAA NIH HHS R01 AA005965NIAAA NIH HHS R01 AA010723NIAAA NIH HHS R01 AA017923NIAAA NIH HHS R21 AA023582NIAAA NIH HHS R37 AA010723NIAAA NIH HHS U01 AA017923TRAIL Laboratory of Excellence (Labex) TRAIL-ANR-10-LABX-57
6 · The paper itself

Abstract

Alcohol use disorder (AUD) is widely associated with cerebellar dysfunction and altered cerebro-cerebellar functional connectivity (FC) that lead to cognitive impairments. Evidence for this association comes from resting-state functional magnetic resonance imaging (rsfMRI) studies that assess time-averaged measures of FC across the duration of a typical scan. This approach, however, precludes the assessment of potentially FC dynamics happening at faster timescales. In this study, using rsfMRI data, we aim at exploring cerebro-cerebellar FC dynamics in AUD patients (N = 18) and age- and sex-matched controls (N = 18). In particular, we quantified group-level differences in the temporal variability of FC between the posterior cerebellum and large-scale cognitive systems, and we investigated the role of the cerebellum in large-scale brain dynamics in terms of the temporal flexibility and integration of its regions. We found that, relative to controls, the AUD group exhibited significantly greater FC variability between the cerebellum and both the frontoparietal executive control (F

Indexed as

AlcoholismCerebellumMagnetic Resonance ImagingBrainExecutive FunctionHumansAlcohol use disorderCerebellumCerebro-cerebellar networksDynamic functional connectivityResting-state fMRI

Identifiers

PMID33655376
PMCPMC8413394
OpenAlexW3133935858

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.