Evidence map›Paper›PMID 33655281›Full record

ArticlemedRxiv : the preprint server for health sciences2021

Multinational Prevalence of Neurological Phenotypes in Patients Hospitalized with COVID-19.

Trang T Le, Alba Gutiérrez-Sacristán, Jiyeon Son, Chuan Hong, Andrew M South, Brett K Beaulieu-Jones, Ne Hooi Will Loh, Yuan Luo, Michele Morris, Kee Yuan Ngiam and 13 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 12 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 9 institutions in 2 countries.

Trang T LeDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Alba Gutiérrez-SacristánDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Jiyeon SonDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
Chuan HongDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
Andrew M SouthDepartment of Pediatrics, Wake Forest School of Medicine, Winston Salem, NC, USA.
Brett K Beaulieu-JonesDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
Ne Hooi Will LohDepartment of Critical Care, National University Health Systems, Singapore.
Yuan LuoDepartment of Preventive Medicine, Northwestern University, Chicago, IL, USA.
Michele MorrisDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA.
Kee Yuan NgiamDepartment of Surgery, National University Health Systems, Singapore.
Lav P PatelDepartment of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
Malarkodi J SamayamuthuDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA.
Emily SchriverData Analytics Center, University of Pennsylvania Health System, Philadelphia, PA, USA.
Amelia Lm TanDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Jason MooreDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Tianxi CaiDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Gilbert S OmennDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Paul AvillachDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Isaac S KohaneDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
4CE Consortium
Shyam VisweswaranDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA.
Danielle L MoweryDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Zongqi XiaDepartment of Neurology, University of Pittsburgh, PA, USA.
University of Pittsburgh · USHarvard University · USUniversity of Pennsylvania · USNational University Health System · SGNorthwestern University · USUniversity of Kansas Medical Center · USUniversity of Michigan · USUniversity of Pennsylvania Health System · USWake Forest University · US

Funding

Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
The role of angiotensin-(1-7) in hypertension and hypertension-induced heart and kidney damageK23HL148394 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SOUTH, ANDREW MICHAEL · 2020 to 2024
$783k
NCATS NIH HHS UL1 TR001420NHLBI NIH HHS K23 HL148394NHLBI NIH HHS L40 HL148910
6 · The paper itself

Abstract

objectiveNeurological complications can worsen outcomes in COVID-19. We defined the prevalence of a wide range of neurological conditions among patients hospitalized with COVID-19 in geographically diverse multinational populations.

methodsUsing electronic health record (EHR) data from 348 participating hospitals across 6 countries and 3 continents between January and September 2020, we performed a cross-sectional study of hospitalized adult and pediatric patients with a positive SARS-CoV-2 reverse transcription polymerase chain reaction test, both with and without severe COVID-19. We assessed the frequency of each disease category and 3-character International Classification of Disease (ICD) code of neurological diseases by countries, sites, time before and after admission for COVID-19, and COVID-19 severity.

resultsAmong the 35,177 hospitalized patients with SARS-CoV-2 infection, there was increased prevalence of disorders of consciousness (5.8%, 95% confidence interval [CI]: 3.7%-7.8%,

interpretationUsing an international network and common EHR data elements, we highlight an increase in the prevalence of central and peripheral neurological phenotypes in patients hospitalized with SARS-CoV-2 infection, particularly among those with severe disease.

Identifiers

PMID33655281
PMCPMC7924306
OpenAlexW3124897223

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.