Evidence map›Paper›PMID 33655267›Full record

ArticlemedRxiv : the preprint server for health sciences2021

Immune memory in mild COVID-19 patients and unexposed donors from India reveals persistent T cell responses after SARS-CoV-2 infection.

Asgar Ansari, Rakesh Arya, Shilpa Sachan, Someshwar Nath Jha, Anurag Kalia, Anupam Lall, Alessandro Sette, Alba Grifoni, Daniela Weiskopf, Poonam Coshic and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Asgar AnsariVaccine Immunology Laboratory, National Institute of Immunology, New Delhi, 110067, India.
Rakesh AryaDepartment of Biochemistry, All India Institute of Medical Sciences, New Delhi, 110029, India.
Shilpa SachanVaccine Immunology Laboratory, National Institute of Immunology, New Delhi, 110067, India.
Someshwar Nath JhaVaccine Immunology Laboratory, National Institute of Immunology, New Delhi, 110067, India.
Anurag KaliaVaccine Immunology Laboratory, National Institute of Immunology, New Delhi, 110067, India.
Anupam LallDepartment of Transfusion Medicine, All India Institute of Medical Sciences, New Delhi, 110029, India.
Alessandro SetteCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, 92037, USA.
Alba GrifoniCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, 92037, USA.
Daniela WeiskopfCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, 92037, USA.
Poonam CoshicDepartment of Transfusion Medicine, All India Institute of Medical Sciences, New Delhi, 110029, India.
Ashok SharmaDepartment of Biochemistry, All India Institute of Medical Sciences, New Delhi, 110029, India.
Nimesh GuptaVaccine Immunology Laboratory, National Institute of Immunology, New Delhi, 110067, India.
National Institute of Immunology · INAll India Institute of Medical Sciences · INLa Jolla Institute for Immunology · US

Funding

Identifying mechanisms and correlates of long-lasting vaccine-induced immunity to whooping coughU01AI141995 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI PETERS, BJOERN, SETTE, ALESSANDRO · 2019 to 2023
$4.1M
NIAID NIH HHS U01 AI141995
6 · The paper itself

Abstract

Understanding the causes of the diverse outcome of COVID-19 pandemic in different geographical locations is important for the worldwide vaccine implementation and pandemic control responses. We analyzed 42 unexposed healthy donors and 28 mild COVID-19 subjects up to 5 months from the recovery for SARS-CoV-2 specific immunological memory. Using HLA class II predicted peptide megapools, we identified SARS-CoV-2 cross-reactive CD4

Indexed as

B cellsCD4+ T cellsHuman CoronavirusNeutralizing antibodyPre-existing immunity

Identifiers

PMID33655267
PMCPMC7924292
OpenAlexW3105442953

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.