Evidence map›Paper›PMID 33655204›Full record

ArticleEClinicalMedicine2021

Estimating risk of mechanical ventilation and in-hospital mortality among adult COVID-19 patients admitted to Mass General Brigham: The VICE and DICE scores.

Christopher J Nicholson, Luke Wooster, Haakon H Sigurslid, Rebecca H Li, Wanlin Jiang, Wenjie Tian, Christian L Lino Cardenas, Rajeev Malhotra

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EClinicalMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 13 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 13 syntheses or guidelines pooled it, 103 citations in OpenAlex.

  1. Pooled it
  2. Obesity as an independent risk factor for COVID-19 severity and mortality.The Cochrane database of systematic reviews · 2023
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  5. The Association Between the Use of Statins and Clinical Outcomes in Patients with COVID-19: A Systematic Review and Meta-analysis.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2022
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  10. Statins reduce mortality in patients with COVID-19: an updated meta-analysis of 147 824 patients.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Christopher J NicholsonCardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Yawkey 5700; 55 Fruit Street, Boston, MA 02114, United States.
Luke WoosterCase Western Reserve University School of Medicine, Cleveland, Ohio, United States.
Haakon H SigurslidCardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Yawkey 5700; 55 Fruit Street, Boston, MA 02114, United States.
Rebecca H LiCardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Yawkey 5700; 55 Fruit Street, Boston, MA 02114, United States.
Wanlin JiangCardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Yawkey 5700; 55 Fruit Street, Boston, MA 02114, United States.
Wenjie TianCardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Yawkey 5700; 55 Fruit Street, Boston, MA 02114, United States.
Christian L Lino CardenasCardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Yawkey 5700; 55 Fruit Street, Boston, MA 02114, United States.
Rajeev MalhotraCardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Yawkey 5700; 55 Fruit Street, Boston, MA 02114, United States.
Massachusetts General Hospital · USUniversity of Electronic Science and Technology of China · CNUniversity School · US

Funding

MULTIDISCIPLINARY RESEARCH TRAINING IN CARDIOLOGYT32HL007208 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Patrick Thomas Ellinor, David E Sosnovik · 1985 to 2026
$16.1M
NHLBI NIH HHS T32 HL007208
6 · The paper itself

Abstract

backgroundRisk stratification of COVID-19 patients upon hospital admission is key for their successful treatment and efficient utilization of hospital resources. We sought to evaluate the risk factors on admission (including comorbidities, vital signs, and initial laboratory assessment) associated with ventilation need and in-hospital mortality in COVID-19.

methodsWe established a retrospective cohort of COVID-19 patients from Mass General Brigham hospitals. Demographic, clinical, and admission laboratory data were obtained from electronic medical records of patients admitted to the hospital with laboratory-confirmed COVID-19 before May 19, 2020. Multivariable logistic regression analyses were used to construct and validate the Ventilation in COVID Estimator (VICE) and Death in COVID Estimator (DICE) risk scores.

findingsThe entire cohort included 1042 patients (median age, 64 years; 56.8% male). The derivation and validation cohorts for the risk scores included 578 and 464 patients, respectively. We found four factors to be independently predictive for mechanical ventilation requirement (diabetes mellitus, SpO

interpretationThe risk scores developed in this study may help clinicians more appropriately determine which COVID-19 patients will need to be managed with greater intensity.

fundingCOVID-19 Fast Grant (fastgrants.org).

Identifiers

PMID33655204
PMCPMC7906522
OpenAlexW3129365730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.