Evidence map›Paper›PMID 33655093›Full record

ArticleJournal of the Endocrine Society2021

Experience of a Pituitary Clinic for US Military Veterans With Traumatic Brain Injury.

Jonathan Lee, Lindsey J Anderson, Dorota Migula, Kevin C J Yuen, Lisa McPeak, Jose M Garcia

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Metabolic and quality of life effects of growth hormone replacement in patients with TBI and AGHD: A pilot study.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2023
    Observational
  7. Neuroendocrine Disruptions Following Head Injury.Current neurology and neuroscience reports · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jonathan LeeGeriatric Research, Education and Clinical Center (GRECC), VA Puget Sound Health Care System, and Department of Medicine, Division of Gerontology & Geriatric Medicine, University of Washington School of Medicine, Seattle, Washington, USA.
Lindsey J AndersonGeriatric Research, Education and Clinical Center (GRECC), VA Puget Sound Health Care System, and Department of Medicine, Division of Gerontology & Geriatric Medicine, University of Washington School of Medicine, Seattle, Washington, USA.ORCID https://orcid.org/0000-0003-3810-2427
Dorota MigulaGeriatric Research, Education and Clinical Center (GRECC), VA Puget Sound Health Care System, and Department of Medicine, Division of Gerontology & Geriatric Medicine, University of Washington School of Medicine, Seattle, Washington, USA.
Kevin C J YuenBarrow Pituitary Center, Barrow Neurological Institute and St. Joseph's Hospital and Medical Center, University of Arizona College of Medicine and Creighton School of Medicine, Phoenix, Arizona, USA.
Lisa McPeakCenter for Polytrauma Care, Rehabilitation Care Services, VA Puget Sound Health Care System, Seattle, Washington, USA.
Jose M GarciaGeriatric Research, Education and Clinical Center (GRECC), VA Puget Sound Health Care System, and Department of Medicine, Division of Gerontology & Geriatric Medicine, University of Washington School of Medicine, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-4245-1753
University of Washington · USBarrow Neurological Institute · USVA Puget Sound Health Care System · US

Funding

Diabetes, Obesity and Metabolism Training ProgramT32DK007247 · NIDDK · UNIVERSITY OF WASHINGTON · PI GREGORY J MORTON, KRISTINA Marie UTZSCHNEIDER · 1986 to 2026
$10.0M
Improving cancer-related fatigue, sexual dysfunction and quality of life in older men with cancer and androgen deficiencyR01AG061558 · NIA · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI BASARIA, SHEHZAD, DEL FABBRO, EGIDIO · 2019 to 2025
$3.4M
Improving Patient-Important Outcomes with Testosterone Replacement in Hypogonadal Men with a Prior History of CancerR01CA239208 · NCI · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI BASARIA, SHEHZAD, GARCIA, JOSE M. · 2019 to 2025
$3.3M
The Role of Ghrelin and the GHSR-1a receptor in Sarcopenic ObesityI01BX002807 · VA · VA PUGET SOUND HEALTHCARE SYSTEM · PI GARCIA, JOSE M. · 2016 to 2025
–
Neuromuscular electrical stimulation for physical function maintenance during hematopoietic stem cell transplantationIK2RX003245 · VA · VA PUGET SOUND HEALTHCARE SYSTEM · PI Lindsey Anderson · 2020 to 2026
–
BLRD VA I01 BX002807NCI NIH HHS R01 CA239208NIA NIH HHS R01 AG061558NIDDK NIH HHS T32 DK007247RRD VA IK2 RX003245
6 · The paper itself

Abstract

contextTraumatic brain injury (TBI) is considered the "signature" injury of veterans returning from wartime conflicts in Iraq and Afghanistan. While moderate/severe TBI is associated with pituitary dysfunction, this association has not been well established in the military setting and in mild TBI (mTBI). Screening for pituitary dysfunction resulting from TBI in veteran populations is inconsistent across Veterans Affairs (VA) institutions, and such dysfunction often goes unrecognized and untreated.

objectiveThis work aims to report the experience of a pituitary clinic in screening for and diagnosis of pituitary dysfunction.

methodsA retrospective analysis was conducted in a US tertiary care center of veterans referred to the VA Puget Sound Healthcare System pituitary clinic with a history of TBI at least 12 months prior. Main outcome measures included demographics, medical history, symptom burden, baseline hormonal evaluation, brain imaging, and provocative testing for adrenal insufficiency (AI) and adult-onset growth hormone deficiency (AGHD).

resultsFatigue, cognitive/memory problems, insomnia, and posttraumatic stress disorder were reported in at least two-thirds of the 58 patients evaluated. Twenty-two (37.9%) were diagnosed with at least one pituitary hormone deficiency, including 13 (22.4%) AI, 12 (20.7%) AGHD, 2 (3.4%) secondary hypogonadism, and 5 (8.6%) hyperprolactinemia diagnoses; there were no cases of thyrotropin deficiency.

conclusionA high prevalence of chronic AI and AGHD was observed among veterans with TBI. Prospective, larger studies are needed to confirm these results and determine the effects of hormone replacement on long-term outcomes in this setting.

Indexed as

adrenal insufficiencyGHgrowth hormone deficiencyhead traumahypopituitarismTBI

Identifiers

PMID33655093
PMCPMC7903186
OpenAlexW3124237034

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.