ArticleACS central science2021
Automatic Generation of 3D-Printed Reactionware for Chemical Synthesis Digitization using ChemSCAD.
Article in ACS central science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 48 citations in OpenAlex.
- The past, present and future of self-driving laboratories.Nature reviews. Chemistry · 2026Review
- 3D Printing in Biocatalysis and Biosensing: From General Concepts to Practical Applications.Chemistry, an Asian journal · 2024Review
- ERCAD: A Parametric Reactor Design Tool That Enables Rapid Prototyping and Optimization of Electrochemical Reactors through 3D Printing.ACS central science · 2024Article
- Wireless Electrochemical Reactor for Accelerated Exploratory Study of Electroorganic Synthesis.ACS central science · 2023Article
- An autonomous portable platform for universal chemical synthesis.Nature chemistry · 2022Article
- A 3D Printer in the Lab: Not Only a Toy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Digitizing Chemical Synthesis in 3D Printed Reactionware.Angewandte Chemie (International ed. in English) · 2022Article
- Continuous Nanoprecipitation of Polycaprolactone in Additively Manufactured Micromixers.Polymers · 2022Article
- Routescore: Punching the Ticket to More Efficient Materials Development.ACS central science · 2022Article
- Review
- Manufacturing and Application of 3D Printed Photo Fenton Reactors for Wastewater Treatment.International journal of environmental research and public health · 2021Article
- You Wouldn't Download a Molecule! Now, ChemSCAD Makes It Possible.ACS central science · 2021Article
- Current and future trends of additive manufacturing for chemistry applications: a review.Journal of materials science · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe a system, ChemSCAD, for the creation of digital reactors based on the chemical operations, physical parameters, and synthetic sequence to produce a given target compound, to show that the system can translate the gram-scale batch synthesis of the antiviral compound Ribavirin (yield 43% over three steps), the narcolepsy drug Modafinil (yield 60% over three steps), and both batch and flow instances of the synthesis of the anticancer agent Lomustine (batch yield 65% over two steps) in purities greater than or equal to 96%. The syntheses of compounds developed using the ChemSCAD system, including reactor designs and analytical data, can be stored in a database repository, with the information necessary to critically evaluate and improve upon reactionware syntheses being easily shared and versioned.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.