Evidence map›Paper›PMID 33654984›Full record

ArticleBio-protocol2019

Early life ovalbumin sensitization and aerosol challenge for the induction ofallergic airway inflammation in a BALB/c murine model.

Kyle T Mincham, Naomi M Scott, Jean-Francois Lauzon-Joset, Jonatan Leffler, Philip A Stumbles, Patrick G Holt, Deborah H Strickland

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bio-protocol, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kyle T MinchamTelethon Kids Institute, University of Western Australia, Nedlands, Western Australia, Australia.
Naomi M ScottTelethon Kids Institute, University of Western Australia, Nedlands, Western Australia, Australia.
Jean-Francois Lauzon-JosetTelethon Kids Institute, University of Western Australia, Nedlands, Western Australia, Australia.
Jonatan LefflerTelethon Kids Institute, University of Western Australia, Nedlands, Western Australia, Australia.
Philip A StumblesTelethon Kids Institute, University of Western Australia, Nedlands, Western Australia, Australia.
Patrick G HoltTelethon Kids Institute, University of Western Australia, Nedlands, Western Australia, Australia.
Deborah H StricklandTelethon Kids Institute, University of Western Australia, Nedlands, Western Australia, Australia.
The Kids Research Institute Australia · AUUniversity of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The early life period represents a time of immunological plasticity whereby the functionally immature immune system is highly susceptible to environmental stimulation. Perennial aeroallergen and respiratory viral infection induced sporadic episodes of lung inflammation during this temporal window represent major risk factors for initiation of allergic asthmatic disease. Murine models are widely used as an investigative tool to examine the pathophysiology of allergic asthma; however, models in current usage typically do not encapsulate the early life period which represents the time of maximal risk for disease inception in humans. To address this issue, this protocol adapted an experimental animal model of disease for sensitization to ovalbumin during the immediate post-weaning period beginning at 21 days of age. By initially sensitizing mice during this early life post-weaning period, researchers can more closely align experimental allergic airway disease models with the human age group most at risk for asthma development.

Indexed as

Airway inflammationAllergyAsthmaEarly lifeOvalbuminSensitization

Identifiers

PMID33654984
PMCPMC7854073
OpenAlexW2920342656

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.