Evidence map›Paper›PMID 33654939›Full record

ArticleBio-protocol2019

DNase I Chromatin Accessibility Analysis.

Brook S Nepon-Sixt, Mark G Alexandrow

Open access · bronzeAbstract read
In one paragraph

Article in Bio-protocol, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The SMARCA4NPJ precision oncology · 2023
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Brook S Nepon-SixtDepartment of Molecular Oncology, Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
Mark G AlexandrowDepartment of Molecular Oncology, Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
Moffitt Cancer Center · USMolecular Oncology (United States) · US

Funding

Chromatin Remodeling by Cdt1: Role in DNA Replication and TumorigenesisR01CA130865 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI ALEXANDROW, MARK G. · 2010 to 2014
$1.5M
Inhibition of the CMG Helicase as Novel Anti-Neoplastic ApproachR21CA187513 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI ALEXANDROW, MARK G. · 2016 to 2017
$407k
MCM Helicase as a Novel Target for Pancreatic Cancer TreatmentR21CA155393 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI ALEXANDROW, MARK G. · 2011 to 2012
$400k
NCI NIH HHS R01 CA130865NCI NIH HHS R21 CA155393NCI NIH HHS R21 CA187513
6 · The paper itself

Abstract

Chromatin consists of compacted DNA in complex with proteins and contributes to the organization of DNA and its stability. Furthermore, chromatin plays key roles in regulating cellular processes such as DNA replication, transcription, DNA repair, and mitosis. Chromatin assumes more compact (inaccessible) or decondensed (accessible) conformations depending on the function that is being supported in the genome, either locally or globally. The activity of nucleases has been used previously to assess the accessibility of specific genomic regions

Indexed as

Chromatin accessChromatin conformationDNase ILamin B2Origin of DNA replicationqPCR

Identifiers

PMID33654939
PMCPMC7854364
OpenAlexW2994187188

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.