Evidence map›Paper›PMID 33654802›Full record

ArticleBio-protocol2019

Oxygen Consumption Measurements in

Suraiya Haroon, Marc Vermulst

Abstract read
In one paragraph

Article in Bio-protocol, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Form and function of actin impacts actin health and aging.bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. A novelBiology methods & protocols · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Suraiya HaroonDivision of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Marc VermulstLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California, United States.

Funding

Translational Research Training Program in Environmental Health SciencesT32ES019851 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Kara A Bernstein, Trevor M Penning · 2012 to 2026
$6.0M
Delineating the mechanisms and clinical utility of mtDNA mutagenesis in cancerR01CA204894 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HOCKENBERY, DAVID M. · 2017 to 2021
$2.0M
Ultrasensitive measure of human mutagenesis: Connecting the exposome to diseaseR01ES026222 · NIEHS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HOLLAND, ERIC C. · 2016 to 2020
$2.0M
Targeting the IGF-1/insulin signaling pathway to treat mtDNA diseaseR01GM124532 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VERMULST, MARC · 2017 to 2020
$1.2M
NCI NIH HHS R01 CA204894NIEHS NIH HHS R01 ES026222NIEHS NIH HHS T32 ES019851NIGMS NIH HHS R01 GM124532
6 · The paper itself

Abstract

Mitochondria generate 90% of the energy required to sustain life. As a result, loss of mitochondrial function compromises almost every facet of human physiology. Accordingly, most mitochondrial diseases tend to present themselves as complex, multi-systemic disorders that can be difficult to diagnose. Depending on the severity of the mitochondrial dysfunction, the pathology can range from mild discomfort to severe epilepsy, blindness and paralysis. To develop therapies to these diseases, it will be important to optimize experimental techniques that can reliably quantify mitochondrial function, particularly in live cells or intact organisms. Here, we describe how a Seahorse XF24 Analyzer can be used to measure both basal and maximal respiration in the nematode

Indexed as

C. elegansFCCPMaximal respiration capacityMitochondriaOxygen consumptionSeahorse XF24

Identifiers

PMID33654802
PMCPMC7854111

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.