Evidence map›Paper›PMID 33654753›Full record

ArticleBio-protocol2020

Hippocampal Unicellular Recordings and Hippocampal-dependent Innate Behaviors in an Adolescent Mouse Model of Alzheimer's disease.

Siddhartha Mondragón-Rodríguez, Benito Ordaz, Erika Orta-Salazar, Sofia Díaz-Cintra, Fernando Peña-Ortega, George Perry

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bio-protocol, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Siddhartha Mondragón-RodríguezNational Council for Science and Technology (CONACYT), México, México.
Benito OrdazDevelopmental Neurobiology and Neurophysiology, Institute of Neurobiology, National Autonomous University of México (UNAM), Querétaro, México.
Erika Orta-SalazarDevelopmental Neurobiology and Neurophysiology, Institute of Neurobiology, National Autonomous University of México (UNAM), Querétaro, México.
Sofia Díaz-CintraDevelopmental Neurobiology and Neurophysiology, Institute of Neurobiology, National Autonomous University of México (UNAM), Querétaro, México.
Fernando Peña-OrtegaDevelopmental Neurobiology and Neurophysiology, Institute of Neurobiology, National Autonomous University of México (UNAM), Querétaro, México.
George PerryNeuroscience Institute and Department of Biology, College of Sciences, University of Texas at San Antonio (UTSA), San Antonio, Texas.

Funding

RCMI Center for Interdiscplinary Health Research CIHRG12MD007591 · NIMHD · UNIVERSITY OF TEXAS SAN ANTONIO · PI PERRY, GEORGE · 2012 to 2016
$10.4M
NIMHD NIH HHS G12 MD007591
6 · The paper itself

Abstract

Transgenic mice have been used to make valuable contributions to the field of neuroscience and model neurological diseases. The simultaneous functional analysis of hippocampal cell activity combined with hippocampal dependent innate task evaluations provides a reliable experimental approach to detect fine changes during early phases of neurodegeneration. To this aim, we used a merge of patch-clamp with two hippocampal innate behavior tasks. With this experimental approach, whole-cell recordings of CA1 pyramidal cells, combined with hippocampal-dependent innate behaviors, have been crucial for evaluating the early mechanism of neurodegeneration and its consequences. Here, we present our protocol for

Indexed as

HippocampusInnate behaviorNeurodegenerationPatch-clampPyramidal cellsSubthreshold oscillations and Alzheimer’s disease

Identifiers

PMID33654753
PMCPMC7842348

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.