ArticleQuantitative imaging in medicine and surgery2021
Virtually structured detection enables super-resolution ophthalmoscopy of rod and cone photoreceptors in human retina.
Article in Quantitative imaging in medicine and surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Article
- Extracting spacing-derived estimates of rod density in healthy retinae.Biomedical optics express · 2023Article
- Emerging imaging developments in experimental vision sciences and ophthalmology.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Super-resolution ophthalmoscopy: Virtually structured detection for resolution improvement in retinal imaging.Experimental biology and medicine (Maywood, N.J.) · 2021Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHigh resolution imaging is desirable for advanced study and clinical management of retinal diseases. However, spatial resolution of retinal imaging has been limited due to available numerical aperture and optical aberration of the ocular optics. This study is to develop and validate virtually structured detection (VSD) to surpass diffraction limit for resolution improvement in
methodsA rapid line scanning laser ophthalmoscope (SLO) was constructed for
resultsThe VSD based super-resolution SLO significantly improved image quality compared with equivalent wide-field imaging.
conclusionsIn conjunction with rapid line-scan imaging and digital registration to minimize the effect of eye movements, VSD enabled resolution improvement to observe individual retinal photoreceptors without the involvement of adaptive optics (AO). An objective method has been developed to identify MTF to enable quantitative estimation of the cut-off frequency required for robust VSD processing.
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Registered trials
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