ArticleQuantitative imaging in medicine and surgery2021
3D Monte Carlo simulation of light distribution in mouse brain in quantitative photoacoustic computed tomography.
Article in Quantitative imaging in medicine and surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 30 citations in OpenAlex.
- 3D-PAULM: Integrated Photoacoustic Tomography and Ultrasound Localization Microscopy for Multiparametric Brain and Tumor Imaging.bioRxiv : the preprint server for biology · 2026Article
- A contemporary systematic review on deterministic numerical simulations of light propagation in head tissues.Biophysical reviews · 2026Review
- Ultrasound-guided photoacoustic image annotation toolkit in MATLAB (PHANTOM) for preclinical applications.Photoacoustics · 2025Article
- Monte Carlo-Based Optical Simulation of Optical Distribution in Deep Brain Tissues Using Sixteen Optical Sources.Bioengineering (Basel, Switzerland) · 2024Article
- Deep tissue photoacoustic imaging with light and sound.Npj imaging · 2024Review
- 4D spectral-spatial computational photoacoustic dermoscopy.Photoacoustics · 2023Article
- Ultrasound-guided Photoacoustic image Annotation Toolkit in MATLAB (PHANTOM) for preclinical applications.bioRxiv : the preprint server for biology · 2023Article
- Mitigating Under-Sampling Artifacts in 3D Photoacoustic Imaging Using Res-UNet Based on Digital Breast Phantom.Sensors (Basel, Switzerland) · 2023Article
- A Wearable Fiber-Free Optical Sensor for Continuous Monitoring of Cerebral Blood Flow in Freely Behaving Mice.IEEE transactions on bio-medical engineering · 2023Article
- Three-dimensional non-invasive brain imaging of ischemic stroke by integrated photoacoustic, ultrasound and angiographic tomography (PAUSAT).Photoacoustics · 2023Article
- A Comprehensive Review on Photoacoustic-Based Devices for Biomedical Applications.Sensors (Basel, Switzerland) · 2022Review
- Deep thrombosis characterization using photoacoustic imaging with intravascular light delivery.Biomedical engineering letters · 2022Article
- Practical review on photoacoustic computed tomography using curved ultrasound array transducer.Biomedical engineering letters · 2022Review
- Sound out the impaired perfusion: Photoacoustic imaging in preclinical ischemic stroke.Frontiers in neuroscience · 2022Review
- Article
- Development of a digital breast phantom for photoacoustic computed tomography.Biomedical optics express · 2021Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPhotoacoustic computed tomography (PACT) detects light-induced ultrasound (US) waves to reconstruct the optical absorption contrast of the biological tissues. Due to its relatively deep penetration (several centimeters in soft tissue), high spatial resolution, and inherent functional sensitivity, PACT has great potential for imaging mouse brains with endogenous and exogenous contrasts, which is of immense interest to the neuroscience community. However, conventional PACT either assumes homogenous optical fluence within the brain or uses a simplified attenuation model for optical fluence estimation. Both approaches underestimate the complexity of the fluence heterogeneity and can result in poor quantitative imaging accuracy.
methodsTo optimize the quantitative performance of PACT, we explore for the first time 3D Monte Carlo (MC) simulation to study the optical fluence distribution in a complete mouse brain model. We apply the MCX MC simulation package on a digital mouse (Digimouse) brain atlas that has complete anatomy information. To evaluate the impact of the brain vasculature on light delivery, we also incorporate the whole-brain vasculature in the Digimouse atlas. k-wave toolbox was used to investigate the effect of inhomogeneous illumination on the reconstructed images and chromophore concentration estimation.
resultsThe simulation results clearly show that the optical fluence in the mouse brain is heterogeneous at the global level and can decrease by a factor of five with increasing depth. Moreover, the strong absorption and scattering of the brain vasculature also induce the fluence disturbance at the local level.
conclusionsBoth global and local fluence heterogeneity contributes to the reduced quantitative accuracy of the reconstructed PACT images of mouse brain. Correcting the optical fluence distribution can improve the quantitative accuracy of PACT.
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