Evidence map›Paper›PMID 33654666›Full record

ArticleQuantitative imaging in medicine and surgery2021

Optical coherence tomography angiography distortion correction in widefield montage images.

Nihaal Mehta, Yuxuan Cheng, A Yasin Alibhai, Jay S Duker, Ruikang K Wang, Nadia K Waheed

Abstract read
In one paragraph

Article in Quantitative imaging in medicine and surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Observational
  2. Volumetric montaging of optical coherence tomography in human retinas.bioRxiv : the preprint server for biology · 2026
    Article
  3. Strip-Scanning for Efficient Widefield Retinal OCTA Mosaicking.Translational vision science & technology · 2026
    Article
  4. Article
  5. Article
  6. Widefield OCT angiography.Progress in retinal and eye research · 2025
    Review
  7. Advances in OCT Angiography.Translational vision science & technology · 2025
    Review
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nihaal MehtaNew England Eye Center, Tufts Medical Center, Boston, MA, USA.
Yuxuan ChengDepartment of Bioengineering, University of Washington, Seattle, WA, USA.
A Yasin AlibhaiNew England Eye Center, Tufts Medical Center, Boston, MA, USA.
Jay S DukerNew England Eye Center, Tufts Medical Center, Boston, MA, USA.
Ruikang K WangDepartment of Bioengineering, University of Washington, Seattle, WA, USA.
Nadia K WaheedNew England Eye Center, Tufts Medical Center, Boston, MA, USA.

Funding

Ultra-wide field optical coherence tomography based angiography for imaging diabetic retinopathyR01EY028753 · NEI · UNIVERSITY OF WASHINGTON · PI WANG, RUIKANG · 2018 to 2021
$2.2M
NEI NIH HHS R01 EY028753
6 · The paper itself

Abstract

backgroundOptical coherence tomography (OCT) imaging is inherently susceptible to distortion artifacts due to the natural curvature of the eye. This study proposes a novel model for widefield OCT angiography (OCTA) distortion correction and analyzes the effects of this correction on quantification metrics.

methodsWidefield OCTA images were obtained on normal subjects at five fixation spatial positions. Radial and field distortion correction were applied and images stitched together to form a corrected widefield montage image. Vessel area density (VAD), vessel complexity index (VCI), and flow impairment area were quantified on the original and corrected montage images.

resultsThis model allows for distortion correction and montaging of widefield images. There were either statistically insignificant or small magnitude changes in vessel density and vessel complexity between uncorrected and corrected widefield images. There was a significant and large difference in flow impairment area, both in the macular (+8.2%, P=0.049) and peripheral areas (+17.2%, P=0.011), following correction. The relationship between pre- and post-correction flow impairment area was non-linear.

conclusionsDistortion correction of widefield OCTA images can result in clinically and statistically significant differences in important quantification metrics. This effect appears to be most pronounced in the periphery.

Indexed as

distortion correctionmontageOptical coherence tomography angiography (OCTA)quantification metricswidefield imaging

Identifiers

PMID33654666
PMCPMC7829171

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.