ArticleCureus2021
A Novel Case of Cerebral Diplopia Secondary to a Posterior Parietal Cortex Ischemic Infarct: Proposal of a Mechanism of Generation of Polyopia Due to Convergence Insufficiency.
Article in Cureus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
All reported cases of cerebral polyopia in the literature are associated solely with occipital lobe disease, as seen with ischemic infarcts, migraine, trauma, and epilepsy. To our knowledge, this is the first case of polyopia associated with posterior parietal cortex (PPC) ischemic infarct to be reported in the literature. Previous hypotheses about mechanisms of polyopia have included cortical spreading depression, the vague idea of abnormal visual synthesis, and the holographic or holonomic brain theory. We propose a new mechanism due to dysfunction of the network from the PPC [Formula: see text] frontal eye field (FEF) [Formula: see text] paramedian midbrain and pontine reticular formation leading to convergence insufficiency, which leads to horizontal diplopia. The evidence ranging from tracer studies in macaque monkeys to functional MRI (fMRI) studies in patients with convergence insufficiency is presented to bolster our hypothesis. In the process, we also briefly review the neural pathways of convergence.
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