Evidence map›Paper›PMID 33654379›Full record

Trial reportDrug design, development and therapy2021

Addition of Celebrex and Pregabalin to Ropivacaine for Posterior Spinal Surgery: A Randomized, Double-Blinded, Placebo-Controlled Trial.

Ye Zhang, Bin He, Jinqiu Zhao, Muzi Zhang, Qinsong Ren, Wei Zhang, Shuai Xu, Zhengxue Quan, Yunsheng Ou

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug design, development and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 3 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ye Zhang *Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Bin He *Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Jinqiu Zhao *Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Muzi ZhangDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Qinsong RenDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Wei ZhangDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Shuai XuDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Zhengxue QuanDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Yunsheng OuDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
First Affiliated Hospital of Chongqing Medical University · CNChongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSerious pain commonly occurs after posterior spinal surgery. This study aims to evaluate the effect of preemptive and multimodal analgesia using celebrex, pregabalin and ropivacaine on pain control after this surgery.

methodsNinety-three patients undergoing posterior spinal surgery were enrolled in this prospective, randomized, double-blind, placebo-controlled clinical trial. All patients were treated with patient- controlled analgesia (PCA, intravenous tramadol hydrochloride and flurbiprofen) as required. They were randomized to combination analgesia intervention (oral celebrex, pregabalin and subcutaneous infiltration of ropivacaine), ropivacaine intervention (only subcutaneous infiltration of ropivacaine), and control intervention (placebo). We compared postoperative visual analog scale (VAS) scores and PCA dose among the three groups.

resultsThe VAS scores were significantly lower in the combination analgesia group than in the control group at 0 h, 2 h, 12 h, 24 h, 3 d, 5 d, 7 d and 14 d after posterior spinal surgery, while combination analgesia was also superior to ropivacaine in terms of VAS scores at 24 h and 14 d postoperatively. The combination analgesia group was also associated with significantly reduced PCA consumption compared with the control group, but there was no statistical difference in PCA consumption between the ropivacaine group and control group.

conclusionCombination analgesia using celebrex, pregabalin and ropivacaine is effective and safe to alleviate pain after posterior spinal surgery. CLINICAL

trial registrationChinese Clinical Trial Registry No. ChiCTR2000031236.

Indexed as

AdolescentAdultAgedAged, 80 and overAnalgesics, OpioidCelecoxibDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansLumbar VertebraeMaleMiddle AgedMolecular StructurePain MeasurementPostoperative PainAnalgesics, OpioidCelecoxibPregabalinRopivacainemultimodal analgesiapain controlposterior spinal surgerypreemptive analgesiarandomized trial

Identifiers

PMID33654379
PMCPMC7910150
OpenAlexW3132441992

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.