Evidence map›Paper›PMID 33654286›Full record

ArticlePediatric research2022

Mammillary body injury in neonatal encephalopathy: a multicentre, retrospective study.

Maarten H Lequin, Sylke J Steggerda, Mariasavina Severino, Domenico Tortora, Alessandro Parodi, Luca A Ramenghi, Floris Groenendaal, Karlijn M E Meys, Manon J N L Benders, Linda S de Vries and 1 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
6.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 30 citations in OpenAlex.

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  13. Neuroimaging in the term newborn with neonatal encephalopathy.Seminars in fetal & neonatal medicine · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Maarten H LequinDepartment of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands. m.h.lequin@umcutrecht.nl.
Sylke J SteggerdaDepartment of Neonatology, Leiden University Medical Center, Leiden, The Netherlands.
Mariasavina SeverinoNeuroradiology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Domenico TortoraNeuroradiology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Alessandro ParodiNeonatal Intensive Care Unit, Department Mother and Child, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Luca A RamenghiNeonatal Intensive Care Unit, Department Mother and Child, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Floris GroenendaalDepartment of Neonatology, UMC Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.
Karlijn M E MeysDepartment of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Manon J N L BendersDepartment of Neonatology, UMC Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.
Linda S de VriesDepartment of Neonatology, Leiden University Medical Center, Leiden, The Netherlands.
Seralynne D VannSchool of Psychology, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0002-6709-8773
Istituto Giannina Gaslini · ITUtrecht University · NLUniversity Medical Center Utrecht · NLCardiff University · GBLeiden University Medical Center · NL

Funding

Wellcome Trust 212273/Z/18/Wellcome Trust 212273/Z/18/Z
6 · The paper itself

Abstract

backgroundThe mammillary bodies (MBs) have repeatedly been shown to be critical for memory, yet little is known about their involvement in numerous neurological conditions linked to memory impairments, including neonatal encephalopathy.

methodsWe implemented a multicentre retrospective study, assessing magnetic resonance scans of 219 infants with neonatal encephalopathy who had undergone hypothermia treatment in neonatal intensive care units located in the Netherlands and Italy.

resultsAbnormal MB signal was observed in ~40% of infants scanned; in half of these cases, the brain appeared otherwise normal. MB involvement was not related to the severity of encephalopathy or the pattern/severity of hypoxic-ischaemic brain injury. Follow-up scans were available for 18 cases with abnormal MB signal; in eight of these cases, the MBs appeared severely atrophic.

conclusionsThis study highlights the importance of assessing the status of the MBs in neonatal encephalopathy; this may require changes to scanning protocols to ensure that the slices are sufficiently thin to capture the MBs. Furthermore, long-term follow-up of infants with abnormal MB signal is needed to determine the effects on cognition, which may enable the use of early intervention strategies. Further research is needed to assess the role of therapeutic hypothermia in MB involvement in neonatal encephalopathy. IMPACT: The MBs are particularly sensitive to hypoxia in neonates. Current hypothermia treatment provides incomplete protection against MB injury. MB involvement is likely overlooked as it can often occur when the rest of the brain appears normal. Given the importance of the MBs for memory, it is necessary that this region is properly assessed in neonatal encephalopathy. This may require improvements in scanning protocols.

Indexed as

HypothermiaHypothermia, InducedHypoxia-Ischemia, BrainInfant, Newborn, DiseasesHumansInfantInfant, NewbornMammillary BodiesRetrospective Studies

Identifiers

PMID33654286
PMCPMC9411062
OpenAlexW3134956291

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.