ArticlePediatric research2022
Autonomic development in preterm infants is associated with morbidity of prematurity.
Article in Pediatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- A Review on the Vagus Nerve and Autonomic Nervous System During Fetal Development: Searching for Critical Windows.Frontiers in neuroscience · 2021Pooled it
- The developing relationship between circadian rhythm and heart rate variability in premature infants.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Quantitative measures of autonomic cardiorespiratory maturation in preterm infants are associated with brain volumes at term age.Early human development · 2026Article
- Review
- Autonomic nervous system maturation in preterm neonates: Correlation with gestational and postmenstrual age (ProMote).PloS one · 2026Article
- Visual and motor skills development in preterm and full-term infants: A protocol for longitudinal data collection.MethodsX · 2025Article
- Cardiorespiratory mechanisms triggered during music perception in preterm infants and adults.iScience · 2025Article
- Impact of Depressive Symptoms during the Second Trimester of Pregnancy on Maternal and Fetal Heart Rate Variability.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Article
- Impact of Kangaroo mother care on autonomic cardiovascular control in foetal-growth-restricted preterm infants.Pediatric research · 2025Article
- Third-Trimester Development of Central Autonomic Network Connectivity Is Altered in an Extrauterine Environment.Neonatology · 2025Article
- Circadian rhythm development in preterm infants. The role of postnatal versus postmenstrual age.Early human development · 2024Article
- Central Autonomic Network and Heart Rate Variability in Premature Neonates.Developmental neuroscience · 2024Article
- Article
- Contemporary Understanding of the Central Autonomic Nervous System in Fetal-Neonatal Transition.Seminars in pediatric neurology · 2023Article
- Bedside tracking of functional autonomic age in preterm infants.Pediatric research · 2023Article
- Autonomic markers of extubation readiness in premature infants.Pediatric research · 2023Article
- Cardiac Asystole at Birth Re-Visited: Effects of Acute Hypovolemic Shock.Children (Basel, Switzerland) · 2023Review
- In infants with congenital heart disease autonomic dysfunction is associated with pre-operative brain injury.Pediatric research · 2022Article
- Osteopathic Manipulative Treatment Regulates Autonomic Markers in Preterm Infants: A Randomized Clinical Trial.Healthcare (Basel, Switzerland) · 2022Article
- Entropy Analysis of Neonatal Electrodermal Activity during the First Three Days after Birth.Entropy (Basel, Switzerland) · 2022Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundPrevious studies have described an association between preterm birth and maturation of the autonomic nervous system (ANS); however, this may be impacted by multiple factors, including prematurity-related complications. Our aim was to evaluate for the effect of prematurity-related morbidity on ANS development in preterm infants in the NICU.
methodsWe compared time and frequency domains of heart rate variability (HRV) as a measure of ANS tone in 56 preterm infants from 2 NICUs (28 from each). One cohort was from a high-morbidity regional referral NICU, the other from a community-based inborn NICU with low prematurity-related morbidity. Propensity score matching was used to balance the groups by a 1:1 nearest neighbor design. ANS tone was analyzed.
resultsThe two cohorts showed parallel maturational trajectory of the alpha 1 time-domain metric, with the cohort from the high-morbidity NICU having lower autonomic tone. The maturational trajectories between the two cohorts differed in all other time-domain metrics (alpha 2, RMS1, RMS2). There was no difference between groups by frequency-domain metrics.
conclusionsPrematurity-associated morbidities correlate with autonomic development in premature infants and may have a greater impact on the extrauterine maturation of this system than birth gestational age. IMPACT: Autonomic nervous system development measured by time-domain metrics of heart rate variability correlate with morbidities associated with premature birth. This study builds upon our previously published work that showed that development of autonomic tone was not impacted by gestational age at birth. This study adds to our understanding of autonomic nervous system development in a preterm extrauterine environment. Our study suggests that gestational age at birth may have less impact on autonomic nervous system development than previously thought.
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