Evidence map›Paper›PMID 33654250›Full record

ArticleThe Journal of antibiotics2021

Aldsulfin, a novel unusual anti-mannheimiosis epithiodiketopiperazine antibiotic produced by Lasiodiplodia pseudotheobromae FKI-4499.

Kazunari Sakai, Masato Iwatsuki, Masato Iizuka, Yukihiro Asami, Kenichi Nonaka, Rokuro Masuma, Mami Takizawa, Takuji Nakashima, Toshiyuki Tokiwa, Kazuro Shiomi and 1 more

Abstract read
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In one paragraph

Article in The Journal of antibiotics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Indole-3-Carboxylic Acid From the Endophytic FungusFrontiers in cellular and infection microbiology · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kazunari SakaiŌmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan.ORCID http://orcid.org/0000-0002-4709-3393
Masato IwatsukiŌmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan. iwatuki@lisci.kitasato-u.ac.jp.ORCID http://orcid.org/0000-0001-8373-4314
Masato IizukaGraduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.
Yukihiro AsamiŌmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan.ORCID http://orcid.org/0000-0003-1821-9169
Kenichi NonakaŌmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan.
Rokuro MasumaŌmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan.
Mami TakizawaGraduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.
Takuji NakashimaŌmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan.
Toshiyuki TokiwaŌmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan.
Kazuro ShiomiŌmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan.
Satoshi ŌmuraŌmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An anti-mannheimiosis agent, aldsulfin, was isolated from a culture broth of the fungus Lasiodiplodia pseudotheobromae FKI-4499, together with a known compound, lasiodipline C, using bioassay-guided fractionation. Spectroscopic analysis of aldsulfin, using NMR, mass spectrometry, and CD analyses revealed it to be an epithiodiketopiperazine with an unstable and unusual hemithioaminal moiety. Aldsulfin showed antibacterial activity against Mannheimia haemolytica and Pasteurella multocida.

Indexed as

Anti-Bacterial AgentsAscomycotaCulture MediaDiketopiperazinesDrug Evaluation, PreclinicalFermentationMagnetic Resonance SpectroscopyMannheimia haemolyticaMicrobial Sensitivity TestsMolecular StructurePasteurella multocidaAnti-Bacterial AgentsCulture MediaDiketopiperazines

Identifiers

PMID33654250

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.