Evidence map›Paper›PMID 33654248›Full record

SynthesisHypertension research : official journal of the Japanese Society of Hypertension2021

Hypertension, cardiovascular disease, and nocturia: a systematic review of the pathophysiological mechanisms.

Mitsuru Ohishi, Takuro Kubozono, Koji Higuchi, Yuichi Akasaki

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Hypertension research : official journal of the Japanese Society of Hypertension, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Evidence for the relation between obesity and nocturnal blood pressure patterns.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Article
  11. Review
  12. Nocturia and obstructive sleep apnoea.Nature reviews. Urology · 2024
    Review
  13. Article
  14. Insights into the associative role of hypertension and angiotensin II receptor in lower urinary tract dysfunction.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Review
  15. Observational
  16. Article
  17. Seasonal variation in blood pressure: current evidence and recommendations for hypertension management.Hypertension research : official journal of the Japanese Society of Hypertension · 2021
    Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mitsuru OhishiDepartment of Cardiovascular Medicine and Hypertension, Kagoshima University, Graduate School of Medical and Dental Sciences, Kagoshima, Japan. ohishi@m2.kufm.kagoshima-u.ac.jp.
Takuro KubozonoDepartment of Cardiovascular Medicine and Hypertension, Kagoshima University, Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Koji HiguchiDepartment of Cardiovascular Medicine and Hypertension, Kagoshima University, Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Yuichi AkasakiDepartment of Cardiovascular Medicine and Hypertension, Kagoshima University, Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Kagoshima University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nocturia significantly impairs quality of life, especially in the elderly population, and urinary retention is a main target of treatment for urologists. In addition to nocturia, cardiovascular diseases are common in the elderly population, and a systematic review showed that hypertension and heart failure are often associated with nocturia. One possible pathogenic mechanism underlying the development of hypertension is an increase in blood pressure due to excessive salt intake in people with high-salt sensitivity. From Guyton's natriuretic curve, we can infer that salt-sensitive hypertensive patients who consume too much salt do not excrete salt during the daytime and are forced to excrete salt at night, resulting in increased urine production and nocturia. In patients with heart failure, the nocturnal supine position leads to an increase in central fluid volume due to an increase in venous return from the periphery, and the secretion of natriuretic peptide is stimulated by the stretching of the atria and ventricles. Thus, natriuresis due to hypertension and hydrodiuresis due to heart failure may cause nocturia, which can effectively be treated by the administration of thiazide diuretics and loop diuretics in the morning, respectively. Because cardiovascular diseases, such as hypertension and heart failure, can cause nocturia and because the treatment methods differ depending on the cause, it is necessary to pay close attention to nocturia in the management of lifestyle-related diseases, such as cardiovascular disease.

Indexed as

Cardiovascular DiseasesHypertensionNocturiaAgedHumansNatriuresisNocturiaNocturnal hypertensionNocturnal polyuriaWater diuresis

Identifiers

PMID33654248
OpenAlexW3134074786

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.