ArticleJournal of human hypertension2022
Impact of cardiovascular risk factors on myocardial work-insights from the STAAB cohort study.
Article in Journal of human hypertension, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05960604 (Observational Study to Evaluate the Pressure Recording Analytical Method Parameters in Patients Susceptible to Post-induction Hypotension Due to Hypertension, Diabetes Mellitus, Cardiovascular Risk Factors, or Major Surgery), which is not on this map. Cited by 19 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Observational Study to Evaluate the Pressure Recording Analytical Method Parameters in Patients Susceptible to Post-induction Hypotension Due to Hypertension, Diabetes Mellitus, Cardiovascular Risk Factors, or Major Surgery
Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Myocardial work analysis during semi-supine stress echocardiography: exercise response patterns in heart failure patients and controls.European heart journal. Imaging methods and practice · 2026Article
- Long-term prognostic value of myocardial work analysis across obesity stages: insights from a community-based study.International journal of obesity (2005) · 2025Article
- Non-invasive left ventricular pressure-strain loop in predicting coronary artery occlusion in patients with non-ST segment elevation acute coronary syndrome: a cohort study.The international journal of cardiovascular imaging · 2025Article
- Assessment of ventricular-arterial coupling in early stage middle-aged hypertensives.Journal of human hypertension · 2025Observational
- Assessment of Ventricular-Arterial Coupling in Early Stage Middle-Aged Hypertensives.Research square · 2025Article
- The impact of hypercortisolism beyond metabolic syndrome on left ventricular performance: a myocardial work analysis.Cardiovascular diabetology · 2025Article
- Long-term cardiovascular consequences of cancer therapy-related cardiac dysfunction: insights from ventricular-arterial coupling and myocardial work.European heart journal. Imaging methods and practice · 2025Article
- Effects of weight loss after sleeve gastrectomy on left ventricular myocardial work in obese patients.Frontiers in cardiovascular medicine · 2025Article
- Obesity: the perfect storm for heart failure.ESC heart failure · 2024Review
- Prognostic Utility of Pericardial Effusion in the General Population: Findings From the STAAB Cohort Study.Journal of the American Heart Association · 2024Article
- Longitudinal strain and myocardial work in symptomatic patients having recovered from COVID-19 and possible associations with the severity of the disease.The international journal of cardiovascular imaging · 2024Article
- Hypertensive Heart Disease: Mechanisms, Diagnosis and Treatment.Reviews in cardiovascular medicine · 2024Review
- A cross-sectional study of factors influencing left ventricular myocardial work in peritoneal dialysis patients.Heliyon · 2024Article
- Non-invasive left ventricular pressure-strain loop study on cardiac fibrosis in primary aldosteronism: a comparative study with cardiac magnetic resonance imaging.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Observational
- Myocardial Work in Middle-Aged Adults with Overweight and Obesity: Associations with Sex and Central Arterial Stiffness.Journal of clinical medicine · 2023Article
- Serial Non-Invasive Myocardial Work Measurements for Patient Risk Stratification and Early Detection of Cancer Therapeutics-Related Cardiac Dysfunction in Breast Cancer Patients: A Single-Centre Observational Study.Journal of clinical medicine · 2023Article
- Current and novel echocardiographic assessment of left ventricular systolic function in aortic stenosis-A comprehensive review.Echocardiography (Mount Kisco, N.Y.) · 2022Review
- Strain Imaging for the Early Detection of Cardiac Remodeling and Dysfunction in Primary Aldosteronism.Diagnostics (Basel, Switzerland) · 2022Review
- The Role of Imaging in Cardiovascular Prevention: A Comprehensive Review.Journal of cardiovascular echographyReview
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myocardial work is a new echocardiography-based diagnostic tool, which allows to quantify left ventricular performance based on pressure-strain loops, and has been validated against invasively derived pressure-volume measurements. Myocardial work is described by its components (global constructive work [GCW], global wasted work [GWW]) and indices (global work index [GWI], global work efficiency [GWE]). Applying this innovative concept, we characterized the prevalence and severity of subclinical left ventricular compromise in the general population and estimated its association with cardiovascular (CV) risk factors. Within the Characteristics and Course of Heart Failure STAges A/B and Determinants of Progression (STAAB) cohort study we comprehensively phenotyped a representative sample of the population of Würzburg, Germany, aged 30-79 years. Indices of myocardial work were determined in 1929 individuals (49.3% female, mean age 54 ± 12 years). In multivariable analysis, hypertension was associated with a mild increase in GCW, but a profound increase in GWW, resulting in higher GWI and lower GWE. All other CV risk factors were associated with lower GCW and GWI, but not with GWW. The association of hypertension and obesity with GWI was stronger in women. We conclude that traditional CV risk factors impact selectively and gender-specifically on left ventricular myocardial performance, independent of systolic blood pressure. Quantifying active systolic and diastolic compromise by derivation of myocardial work advances our understanding of pathophysiological processes in health and cardiac disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.