Trial reportScientific reports2021
Clustering of eyes with age-related macular degeneration or pachychoroid spectrum diseases based on choroidal thickness profile.
Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Short-term outcomes and choroidal morphological changes following aflibercept therapy in pachychoroid neovasculopathy.Scientific reports · 2026Trial
- Pachychoroid diseases of the macula: an update.Medical hypothesis, discovery & innovation ophthalmology journal · 2026Review
- Geographic atrophy in Asia.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Review
- Retrospective evaluation of changes in choroidal thickness after cataract surgery.European journal of medical research · 2025Article
- Coefficient of spatial variance of choroidal thickness on swept-source optical coherence tomography in healthy eyes.International ophthalmology · 2024Article
- Impact of Brightness on Choroidal Vascularity Index.Journal of clinical medicine · 2024Article
- Integrity of the Hyperreflective Layer in the Inner Choroid in Eyes with Drusen.Ophthalmology and therapy · 2024Article
- Influence of lesion location on lesion reactivation after initial treatment in neovascular age-related macular degeneration.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- An Analysis of the Usage of Retinal Imaging Technology in the Detection of Age-Related Macular Degeneration.Cureus · 2023Review
- Early Stages of Age-Related Macular Degeneration: Racial/Ethnic Differences and Proposal of a New Classification Incorporating Emerging Concept of Choroidal Pathology.Journal of clinical medicine · 2022Review
- Differentiating a pachychoroid and healthy choroid using an unsupervised machine learning approach.Scientific reports · 2022Article
- Relationship between Pachychoroid and Polypoidal Choroidal Vasculopathy.Journal of clinical medicine · 2022Review
- Factors related to the location of pigment epithelial detachment in central serous chorioretinopathy.Scientific reports · 2022Article
- Peripapillary Choroidal Vascularity Outside the Macula in Patients With Central Serous Chorioretinopathy.Translational vision science & technology · 2021Article
- Choroidal Thickness Profile in Chorioretinal Diseases: Beyond the Macula.Frontiers in medicine · 2021Review
- Pachychoroid Spectrum Disorders: An Updated Review.Journal of ophthalmic & vision researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Choroidal changes have been suggested to be involved in the pathophysiology of both age-related macular degeneration (AMD) and pachychoroid spectrum diseases (PSD). To find out the choroidal characteristics of each disease groups, various groups of AMD and PSD were classified into several clusters according to choroidal profiles based on subfoveal choroidal thickness (CT), peripapillary CT, the ratio of subfoveal CT to peripapillary CT and age. We retrospectively analyzed 661 eyes, including 190 normal controls and 471 with AMD or PSDs. In the AMD groups, eyes with soft drusen or reticular pseudodrusen were belonged to the same cluster as those with classic exudative AMD (all p < 0.001). However, eyes with pachydrusen were not clustered with eyes from other AMD groups; instead, they were classified in the same cluster as eyes from the PSD group (all p < 0.001). In the PSD group, eyes with pachychoroid neovasculopathy were grouped in the same cluster of those with polypoidal choroidal vasculopathy (p < 0.001). The cluster analysis based on the CT profiles, including subfoveal CT, peripapillary CT, and their ratio, revealed a clustering pattern of eyes with AMD and PSDs. These findings support the suggestion that pachydrusen has the common pathogenesis as PSD.
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