ArticleScientific reports2021
First evidence for the presence of amino acid sensing mechanisms in the fish gastrointestinal tract.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 42 citations in OpenAlex.
- Dietary responses of taste receptor genes to plant-based diets in farmed fish: A literature review.Open veterinary journal · 2026Review
- The Emerging Roles of Metabolite-Activated GPCRs in Teleost Physiology and Aquaculture Development.Metabolites · 2025Review
- Activation profile of the Atlantic salmon (Salmo salar) calcium-sensing receptor (Casr) by selected L-amino acids.Scientific reports · 2025Article
- Interaction of dietary replacements of fishmeal by protein blend and feeding frequency on growth performance and protein utilization of gibel carp (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Ectopic taste receptors in animal physiology: evolutionary conservation and functional diversification.Frontiers in cell and developmental biology · 2025Review
- Effects of a Plant-Based Diet During the First Month of Feeding on Alevin Rainbow Trout (Aquaculture nutrition · 2025Article
- Review
- Article
- A vertebrate-wide catalogue of T1R receptors reveals diversity in taste perception.Nature ecology & evolution · 2024Article
- Effects of the Replacement of Dietary Fishmeal by the Blend ofAquaculture nutrition · 2024Article
- Fatty Acid Sensing in the Gastrointestinal Tract of Rainbow Trout: Different to Mammalian Model?International journal of molecular sciences · 2023Article
- Recent advances in the crosstalk between adipose, muscle and bone tissues in fish.Frontiers in endocrinology · 2023Review
- Exploring the potential for an evolutionarily conserved role of the taste 1 receptor gene family in gut sensing mechanisms of fish.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Salinity-dependent expression of calcium-sensing receptors in Atlantic salmon (Salmo salar) tissues.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
This study aimed to characterize amino acid sensing systems in the gastrointestinal tract (GIT) of the carnivorous fish model species rainbow trout. We observed that the trout GIT expresses mRNAs encoding some amino acid receptors described in mammals [calcium-sensing receptor (CaSR), G protein-coupled receptor family C group 6 member A (GPRC6A), and taste receptors type 1 members 1 and 2 (T1r1, T1r2)], while others [taste receptor type 1 member 3 (T1r3) and metabotropic glutamate receptors 1 and 4 (mGlur1, mGlur4)] could not be found. Then, we characterized the response of such receptors, as well as that of intracellular signaling mechanisms, to the intragastric administration of L-leucine, L-valine, L-proline or L-glutamate. Results demonstrated that casr, gprc6a, tas1r1 and tas1r2 mRNAs are modulated by amino acids in the stomach and proximal intestine, with important differences with respect to mammals. Likewise, gut amino acid receptors triggered signaling pathways likely mediated, at least partly, by phospholipase C β3 and β4. Finally, the luminal presence of amino acids led to important changes in ghrelin, cholecystokinin, peptide YY and proglucagon mRNAs and/or protein levels. Present results offer the first set of evidence in favor of the existence of amino acid sensing mechanisms within the fish GIT.
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