Analysis of segmentation ontology reveals the similarities and differences in connectivity onto L2/3 neurons in mouse V1.

Alexander P Y Brown, Lee Cossell, Molly Strom, Adam L Tyson, Mateo Vélez-Fort, Troy W Margrie

Abstract read

In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

Layer 6 corticocortical neurons are a major route for intra- and interhemispheric feedback.eLife · 2025
Article
Cortical Integration of Vestibular and Visual Cues for Navigation, Visual Processing, and Perception.Annual review of neuroscience · 2023
Review
Pyramidal neurons form active, transient, multilayered circuits perturbed by autism-associated mutations at the inception of neocortex.Cell · 2023
Article
Quantitative analysis of rabies virus-based synaptic connectivity tracing.PloS one · 2023
Article
A deep learning algorithm for 3D cell detection in whole mouse brain image datasets.PLoS computational biology · 2021
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexander P Y Brown *Sainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, 25 Howland Street, London, W1T 4JG, UK.

Lee Cossell *Sainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, 25 Howland Street, London, W1T 4JG, UK.

Molly StromSainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, 25 Howland Street, London, W1T 4JG, UK.

Adam L TysonSainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, 25 Howland Street, London, W1T 4JG, UK.

Mateo Vélez-FortSainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, 25 Howland Street, London, W1T 4JG, UK.

Troy W MargrieSainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, 25 Howland Street, London, W1T 4JG, UK. t.margrie@ucl.ac.uk.

Funding

Wellcome TrustWellcome Trust 090843/F/09/ZWellcome Trust 214333/Z/18/Z

6 · The paper itself

Abstract

Quantitatively comparing brain-wide connectivity of different types of neuron is of vital importance in understanding the function of the mammalian cortex. Here we have designed an analytical approach to examine and compare datasets from hierarchical segmentation ontologies, and applied it to long-range presynaptic connectivity onto excitatory and inhibitory neurons, mainly located in layer 2/3 (L2/3), of mouse primary visual cortex (V1). We find that the origins of long-range connections onto these two general cell classes-as well as their proportions-are quite similar, in contrast to the inputs on to a cell type in L6. These anatomical data suggest that distal inputs received by the general excitatory and inhibitory classes of neuron in L2/3 overlap considerably.

Indexed as

Primary Visual CortexAnimalsMiceMice, TransgenicNerve NetNeuronsSynapses

Identifiers

PMID33654118

DOI10.1038/s41598-021-82353-7

PMCPMC7925549

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.