ArticleNature communications2021
Imine as a linchpin approach for meta-C-H functionalization.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The trial behind it
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Who cites it
15 citing papers in PubMed.
- Monodentate Transient Directing Group Enabled Distal C─H Bond Functionalization in Ferrocenecarboxaldehyde.Chemistry, an Asian journal · 2026Article
- Recent advances in synthetic approaches for bioactive cinnamic acid derivatives.Beilstein journal of organic chemistry · 2025Review
- Hydrogen bonding template enables remote meta-C-H alkenylation of nitroarenes with electron-deficient alkenes.Nature communications · 2024Article
- Regioselective Hydroxylation of Unsymmetrical Ketones Using Cu, HThe Journal of organic chemistry · 2024Article
- The crucial role of silver(I)-salts as additives in C-H activation reactions: overall analysis of their versatility and applicability.Chemical Society reviews · 2023Review
- MacrocyclizationChemical science · 2023Article
- Transition-Metal-Catalyzed C-H Bond Activation for the Formation of C-C Bonds in Complex Molecules.Chemical reviews · 2023Review
- Ru(II)-Catalyzed Hydroarylation of in situ Generated 3,3,3-Trifluoro-1-propyne by C-H Bond Activation: A Facile and Practical Access to β-Trifluoromethylstyrenes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Pd(ii)-catalyzedChemical science · 2022Article
- Amine-Catalyzed Copper-Mediated C-H Sulfonylation of Benzaldehydes via a Transient Imine Directing Group.Angewandte Chemie (International ed. in English) · 2022Article
- Transient directing group enabled Pd-catalyzed C-H oxygenation of benzaldehydes and benzylic amines.RSC advances · 2022Article
- RhodiumChemical science · 2022Article
- Directing group assisted rhodium catalyzedChemical science · 2022Article
- OvercomingChemical science · 2022Article
- Recent development in transition metal-catalysed C-H olefination.Chemical science · 2021Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the widespread applications of C-H functionalization, controlling site selectivity remains a significant challenge. Covalently attached directing groups (DGs) served as ancillary ligands to ensure ortho-, meta- and para-C-H functionalization over the last two decades. These covalently linked DGs necessitate two extra steps for a single C-H functionalization: introduction of DG prior to C-H activation and removal of DG post-functionalization. Here we report a temporary directing group (TDG) for meta-C-H functionalization via reversible imine formation. By overruling facile ortho-C-H bond activation by imine-N atom, a suitably designed pyrimidine-based TDG successfully delivered selective meta-C-C bond formation. Application of this temporary directing group strategy for streamlining the synthesis of complex organic molecules without any necessary pre-functionalization at the meta position has been explored.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.