ArticleNPJ Parkinson's disease2021
Thalamic morphology predicts the onset of freezing of gait in Parkinson's disease.
Article in NPJ Parkinson's disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 37 citations in OpenAlex.
- Freezing of Gait: A Tribute to Nir Giladi.The European journal of neuroscience · 2026Article
- Towards the Prevention of Freezing of Gait in Parkinson's Disease.The European journal of neuroscience · 2026Review
- Freezing of Gait Levodopa Response Pattern in Parkinson's Disease Provides Clues to Pathophysiology.The European journal of neuroscience · 2026Review
- Longitudinal changes in effective connectivity associated with worsening freezing of gait in Parkinson's disease: a resting-state functional MRI study.Journal of neurology · 2026Observational
- Distinct cortical excitability and connectivity profiles within the human SMA complex.bioRxiv : the preprint server for biology · 2026Article
- Grey matter atrophy patterns of mobility shared across older adults with and without multiple sclerosis.Journal of neurology · 2025Article
- Differential pathological dynamics triggered by distinct Parkinson patient-derived α-synuclein extracts in nonhuman primates.Science advances · 2025Article
- Atrophy of ventral diencephalon is associated with freezing of gait in Parkinson's disease: analysis of two cohorts.NPJ Parkinson's disease · 2025Article
- Reduced volume of the mediodorsal and anteroventral thalamus is associated with anxiety in Parkinson's disease: A cross-sectional 7-tesla MRI study.Journal of Parkinson's disease · 2025Article
- Thalamic functional connectivity on 7-Tesla magnetic resonance imaging and its relation to motor signs in early-stage Parkinson's disease.Quantitative imaging in medicine and surgery · 2025Article
- A worldwide study of subcortical shape as a marker for clinical staging in Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Regional structural abnormalities in thalamus in idiopathic cervical dystonia.BMC neurology · 2024Article
- The longitudinal volumetric and shape changes of subcortical nuclei in Parkinson's disease.Scientific reports · 2024Article
- A meta-analysis identifies factors predicting the future development of freezing of gait in Parkinson's disease.NPJ Parkinson's disease · 2023Review
- Toward More Accessible Fully Automated 3D Volumetric MRI Decision Trees for the Differential Diagnosis of Multiple System Atrophy, Related Disorders, and Age-Matched Healthy Subjects.Cerebellum (London, England) · 2023Article
- Levodopa responsive freezing of gait is associated with reduced norepinephrine transporter binding in Parkinson's disease.Neurobiology of disease · 2023Article
- Clinical and MRI features of gait and balance disorders in neurodegenerative diseases.Journal of neurology · 2023Review
- Machine learning within the Parkinson's progression markers initiative: Review of the current state of affairs.Frontiers in aging neuroscience · 2023Review
- Gait Declines Differentially in, and Improves Prediction of, People with Parkinson's Disease Converting to a Freezing of Gait Phenotype.Journal of Parkinson's disease · 2023Article
- Regional homogeneity and functional connectivity of freezing of gait conversion in Parkinson's disease.Frontiers in aging neuroscience · 2023Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The onset of freezing of gait (FOG) in Parkinson's disease (PD) is a critical milestone, marked by a higher risk of falls and reduced quality of life. FOG is associated with alterations in subcortical neural circuits, yet no study has assessed whether subcortical morphology can predict the onset of clinical FOG. In this prospective multimodal neuroimaging cohort study, we performed vertex-based analysis of grey matter morphology in fifty-seven individuals with PD at study entry and two years later. We also explored the behavioral correlates and resting-state functional connectivity related to these local volume differences. At study entry, we found that freezers (N = 12) and persons who developed FOG during the course of the study (converters) (N = 9) showed local inflations in bilateral thalamus in contrast to persons who did not (non-converters) (N = 36). Longitudinally, converters (N = 7) also showed local inflation in the left thalamus, as compared to non-converters (N = 36). A model including sex, daily levodopa equivalent dose, and local thalamic inflation predicted conversion with good accuracy (AUC: 0.87, sensitivity: 88.9%, specificity: 77.8%). Exploratory analyses showed that local thalamic inflations were associated with larger medial thalamic sub-nuclei volumes and better cognitive performance. Resting-state analyses further revealed that converters had stronger thalamo-cortical coupling with limbic and cognitive regions pre-conversion, with a marked reduction in coupling over the two years. Finally, validation using the PPMI cohort suggested FOG-specific non-linear evolution of thalamic local volume. These findings provide markers of, and deeper insights into conversion to FOG, which may foster earlier intervention and better mobility for persons with PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.